Early changes in hemorheological parameters and TXA2 and PGI2 levels among patients with severe acute pancreatitis
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摘要: 目的观察重症急性胰腺炎(SAP)患者早期血液流变学指标及血栓素A2(TXA2)、前列环素I2(PGI2)的变化。方法2012年1月至2013年9月住院的32例SAP患者为SAP组,30例体检健康人为NC组。于患者入院后治疗前即静脉采血,平行检测血液流变学指标及血浆TXA2、PGI2水平,并计算TXA2、PGI2比值。结果比较进行t检验。结果 SAP组血液流变学中除红细胞变形指数低于NC组(t=2.185,P<0.05)外,全血高、中、低切黏度、血浆黏度高于NC组(t=2.820、2.755、2.700、3.622,P<0.05),全血高切还原黏度、全血低切还原黏度高于NC组(t=3.391、2.018,P<0.05),红细胞压积、红细胞刚性指数、红细胞聚集指数高于NC组(t=2.980、2.209、2.004,P<0.05)、全血高切相对指数、全血低切相对指数高于NC组(t=2.630、2.440,P<0.05);SAP组TXA2、PGI2、TXA2、PGI2比值高于NC组(t=3.256、2.589、2.640,P<0.05)。结论 SAP患者早期...
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关键词:
- 胰腺炎,急性坏死性 /
- 血液流变学 /
- 受体,血栓烷A2,前列腺素H2 /
- 依前列醇
Abstract: Objective To investigate the early changes in hemorheological parameters and thromboxane A2 ( TXA2) and prostacyclin ( PGI2) levels among patients with severe acute pancreatitis ( SAP) . Methods Thirty-two SAP patients hospitalized from January 2012 to September 2013 were selected as SAP group; 30 healthy controls were selected as normal control ( NC) group. Venous blood was collected after admission and before treatment. The hemorheological parameters and plasma levels of TXA2and PGI2were determined, and TXA2/PGI2ratio was calculated. Comparison between groups was made by t test. Results Compared with the NC group, the SAP group had a significantly lower erythrocyte deformation index ( t = 2. 185, P < 0. 05) , significantly higher whole blood viscosities at high-, middle-, and low- shear rates and plasma viscosity ( t = 2. 820, 2. 755, 2. 700, and 3. 622, P < 0. 05) , significantly higher whole blood reduced viscosities at high- and low- shear rates ( t = 3. 391 and 2. 018, P < 0. 05) , a significantly higher hematocrit ( t = 2. 980, P < 0. 05) , a significantly higher erythrocyte rigidity index ( t = 2. 209, P < 0. 05) , a significantly higher erythrocyte aggregation index ( t = 2. 004, P < 0. 05) , a significantly higher whole blood relative index at high shear rate ( t = 2. 630, P < 0. 05) , a significantly higher whole blood relative index at low shear rate ( t = 2. 440, P < 0. 05) , a significantly higher TXA2level ( t = 3. 256, P < 0. 05) , a significantly higher PGI2level ( t =2. 589, P < 0. 05) , and a significantly higher TXA2/PGI2ratio ( t = 2. 640, P < 0. 05) . Conclusion Hemorheological disorders and increased activity of vascular endothelial cells appear in the early stage in SAP. -
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