Cytokine storm and liver failure
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摘要: 细胞因子风暴(cytokine storm)在肝衰竭发病机制中起十分重要的作用,与肝衰竭过程中的肝细胞坏死和疾病临床预后密切相关。介绍了以Kupffer细胞为线索,肝衰竭发生、发展过程中各相关细胞及细胞因子相互影响、共同作用,导致肝组织严重损伤和坏死的机制。指出细胞因子的研究,将有助于肝衰竭早期诊断、病情分析和个体化治疗水平的提高。Abstract: Cytokine storm plays an important role in the pathogenesis of liver failure. It is closely related to hepatocyte necrosis in the clinical course and the prognosis of this disease. With Kupffer cells as a clue, it is elucidated that related cells and cytokines influence each other and jointly function in the development and progression of liver failure, leading to serious liver tissue damage and necrosis. Cytokine-based research can help improve early diagnosis, disease assessment, and individualized treatment for liver failure.
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Key words:
- liver failure /
- cytokine /
- kupffer cells
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