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摘要: 目的探讨慢性HBV感染者血清瘦素、脂联素水平的变化及意义。方法入选2006年1月至2007年3月北京友谊医院收治的慢性HBV感染者(包括HBeAg抗原阳性和阴性慢性乙型肝炎、慢性HBV携带者、非活动性HBsAg携带者)125例,及正常对照组55例。夜间禁食后于次晨8-9时采取血标本,测定生化指标如血糖、血脂及肝、肾功能、空腹胰岛素(FINS)、HBV血清标志物及HBV DNA等,并计算胰岛素抵抗指数(HOMA-IR);采用ELISA法测定空腹血清瘦素、脂联素。对数据分别进行t检验、方差分析、直线相关分析和多元逐步回归分析。结果与正常对照组相比,HBV感染者血清瘦素、脂联素差异均无统计学意义(P值分别为0.480,0.321);按男女分层后再行比较,两组间瘦素、脂联素水平差异仍无统计学意义(男性:P值分别为0.210,0.895;女性:P值分别为0.404,0.066)。无论是按HBeAg状态、还是按HBV DNA或ALT水平分为不同的亚组,各组间的瘦素、脂联素水平差异均无统计学意义(瘦素:P值分别为0.820,0.296,0.212;脂联素:P值分别为0.268,0.760,0.224...Abstract: Objective To investigate the changes in serum leptin and adiponectin levels and their significance in patients with chronic hepatitis B virus ( HBV) infection. Methods One hundred and twenty-five patients with chronic HBV infection ( 44 HBeAg-positive cases, 31 HBeAg-negative cases of chronic hepatitis B, 23 chronic HBV carriers, and 27 inactive HBsAg carriers) were recruited in the present study. Fifty-five healthy people served as the control group. Blood samples were collected at 8 to 9 AM of the next morning after overnight fasting. Blood glucose, blood lipids, renal and liver function parameters, fasting insulin, serum HBV markers, and HBV DNA concentration were determined, and HOMA-IR was calculated. Serum levels of leptin and adiponectin were measured by ELISA. Continuous data were expressed as mean ± SD, and Student's t-test, analysis of variance, linear regression analysis, and multiple regression analysis were applied in the analysis of all experimental data. Results There were no significant differences in serum levels of leptin and adiponectin between patients with chronic HBV infection and the control group ( P = 0. 480; P = 0. 321) , even after stratification by gender ( males: P =0. 210 /0. 895; females: P = 0. 404 /0. 066) . After patients with chronic HBV infection were divided into subgroups by HBeAg status, HBV DNA, or ALT level, there were no significant differences in serum levels of leptin and adiponectin between groups ( leptin: P = 0. 820 /0. 296 /0. 212; adiponectin: P = 0. 268 /0. 760 /0. 224) . Conclusion For patients with chronic HBV infection, infection status and viral replication level are not significantly correlated with serum levels of leptin and adiponectin.
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Key words:
- hepatitis B, chronic /
- leptin /
- adiponectin
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