Analysis of ERα-29 polymorphisms between Han nationality and Hui minority populations with chronic hepatitis B in Gansu Province, China
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摘要: 目的分析甘肃地区汉族和回族慢性乙型肝炎(CHB)患者雌激素受体(ER)α-29位基因多态性的分布情况。方法选取2012年8月至2013年11月在兰州市第一人民医院就诊的甘肃地区回族及汉族CHB患者各84例。采用聚合酶链反应-限制性片段长度多态性法检测ERα-29位多态性。用基因计数法计算检验人群的等位基因频率,进行Hardy-Weinberg遗传平衡定律检验。应用非条件Logistic回归分析将混杂因素进行调整。基因型及等位基因频率比较采用卡方检验。结果甘肃省汉族、回族CHB人群的ERα-29位点基因型频率:TT为52.4%、60.7%;TC为40.5%、34.5%;CC为7.1%、4.8%。等位基因频率:T为72.6%、78.0%;C为27.4%、22.0%。ERα-29位基因型频率在甘肃汉族、回族CHB患者间的差异无统计学意义(P>0.05)。结论ERα-29位基因多态性在甘肃省汉族、回族CHB人群中无民族差异。Abstract: Objective To investigate the genetic polymorphisms in the estrogen receptor (ER) alpha gene at position 29 (ERα-29) in patients with chronic hepatitis B (CHB) from Han nationality and Hui minority populations in Gansu Province, China. Methods Polymorphisms of ERα-29 were analyzed in 84 Han and 84 Hui CHB patients who were admitted to our hospital from August 2012 to November 2013 by polymerase chain reaction-restriction fragment length polymorphism analysis. Allele frequencies were determined by gene counting and tested for expectations of Hardy-Weinberg equilibrium. Unconditional logistic regression analysis was applied to adjust the confounding factors. Comparison of the genotype and allele frequencies was performed by chi-square test. Results The genotype frequencies of ERα-29 in Han versus Hui CHB patients from Gansu Province were as follows: TT, 52. 4% vs 60. 7%; TC, 40. 5% vs 34. 5%; CC, 7. 1% vs 4. 8%. The allele frequencies were 72. 6% vs 78. 0% for the T allele and 27. 4% vs 22. 0% for the C allele. No significant differences in the allele and genotype frequencies of ERα-29 were found between Han and Hui CHB patients in Gansu Province (P > 0. 05) . Conclusion The genetic polymorphisms in ERα-29 are not significantly different between Han and Hui CHB patients in Gansu Province, China.
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