Efficacy of glycyrrhizin in patients with chronic severe hepatitis B:a meta-analysis
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摘要:
目的系统评价甘草酸类制剂治疗慢性重型乙型肝炎的疗效和安全性。方法利用计算机检索Pub Med、Cochrane Library、CBMdisc、CNKI、维普、万方等数据库1990年1月至2014年7月期间公开发表的文献,纳入甘草酸类制剂联合内科综合治疗与单纯内科综合治疗相比较治疗慢性重型乙型肝炎的随机对照试验。对纳入试验独立进行质量评价和资料提取,采用Rev Man 5.1软件进行Meta分析,并对其中的异质性、敏感性、偏倚作出判断。结果共纳入7项随机对照研究,包括试验组298例和对照组294例患者。分析结果显示,试验组的病死率及TBil低于对照组,差异具有统计学意义[相对危险度(RR)=0.56,95%可信区间(CI):0.420.76,P<0.01;均数差(MD)=-92.56,95%CI:-122.92-62.20,P<0.01];试验组的凝血酶原活动度(PTA)高于对照组,差异具有统计学意义[MD=11.14,95%CI:5.4016.87,P<0.01];所有患者未出现严重不良反应。结论甘草...
Abstract:Objective To systematically evaluate the efficacy and safety of glycyrrhizin in patients with chronic severe hepatitis B.Methods Literature published from January 1990 to July 2014 were searched in databases including Pub Med,Cochrane Library,CBMdisc,CNKI,VIP,and Wanfang Data.The randomized controlled trials comparing the efficacy of glycyrrhizin combined with internal comprehensive therapy versus internal comprehensive therapy alone in patients with chronic severe hepatitis B were included in the analysis.The methodological quality of included trials was independently assessed and the data were extracted.Meta-analysis was carried out with Review Manager Software 5.1,and the heterogeneity,sensitivity,and bias of the analysis were evaluated.Results Seven randomized controlled trials involving298 patients in the test group and 294 in the control group were included in the analysis.The results of meta-analysis showed that glycyrrhizin combined with internal comprehensive therapy was remarkably more effective than internal comprehensive therapy alone,indicated by significantly reduced mortality rate [relative risk(RR) = 0.56,95% confidenceinterval(CI) :0.42 ~ 0.76,P < 0.01],significantly decreased level of total bilirubin(TBil) [mean difference(MD) =-92.56,95% CI:-122.92 ~-62.20,P < 0.01],and significantly higher prothrombin activity(PTA) [mean difference(MD) = 11.14,95% CI:5.40 ~ 16.87,P < 0.01].No severe adverse reactions were found in all patients.Conclusion Glycyrrhizin can significantly reduce the mortality and improve TBil and PTA in patients with chronic severe hepatitis B.
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Key words:
- hepatitis B,chronic /
- glycyrrhizic acid /
- Meta-analysis
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