Clinical effect of transcatheter arterial chemoembolization combined with argon-helium cryoablation in patients with advanced unresectable primary hepatocellular carcinoma
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摘要:
目的观察肝动脉化疗栓塞术(TACE)联合氩氦刀冷冻消融技术治疗不能手术的中晚期肝癌患者的有效性和安全性。方法对2008年5月-2010年6月郑州大学附属洛阳中心医院收治的35例肝癌患者首先行TACE治疗23周,然后行氩氦刀冷冻消融治疗,12周后再次进行TACE治疗,治疗结束后评价近期疗效,并随访生存情况。两组间数据比较采用t检验,生存曲线采用Kaplan-Meier法进行生存分析。结果 35例患者均可评价疗效,其中完全缓解7例,部分缓解21例,稳定4例,进展3例;临床治疗有效率为80.00%,疾病控制率为91.43%;2、3年生存率分别为45.6%、39.4%。35例患者治疗前甲胎蛋白(AFP)为(837.6±216.7)μg/L,治疗后AFP为(206.2±48.6)μg/L,差异有统计学意义(t=2.673,P<0.05)。结论 TACE联合氩氦刀冷冻消融是治疗不能手术的中晚期肝癌患者的可靠方法,具有创伤小、恢复快、并发症少等特点。
Abstract:Objective To evaluate the efficacy and safety of transcatheter arterial chemoembolization(TACE) combined with argon-helium cryoablation in patients with advanced unresectable primary hepatocellular carcinoma(HCC).Methods TACE was performed in 35 patients with primary HCC who were admitted to our hospital from May 2008 to June 2010.After 2-3 weeks of treatment,the patients received argon-helium cryoablation,followed by a second TACE in 1-2 weeks.The short-term efficacy after treatment was evaluated and the long-term survival was studied by follow-up.Comparison between two groups was made by t test,and survival was analyzed using the Kaplan-Meier survival curves.Results The clinical outcomes of all 35 patients were evaluated.Complete response was observed in 7 patients,partial response in 21 patients,stable disease in 4 patients,and progressive disease in 3 patients.The overall response rate was 80.00%,and the disease control rate was 91.43%.The 2-and 3-year survival rates were 45.6% and 39.4%,respectively.The level of alpha-fetoprotein AFP in patients after the treatment(206.2 ± 48.6 μg / L) was significantly lower than that before the treatment(837.6 ±216.7 μg / L)(t = 2.673,P < 0.05).Conclusion TACE combined with argon-helium cryoablation is a reliable therapeutic approach in treating advanced unresectable primary HCC,and the advantages include minimal invasion,fast recovery,and few complications.
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Key words:
- liver neoplasms /
- chemoembolization,therapeutic /
- cryosurgery
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