New progress in development of animal models of hepatitis C virus infection
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摘要: 理想的HCV感染动物模型的建立,不仅有利于研究慢性丙型肝炎的致病机制(包括病毒-宿主相互作用、病毒变异性、宿主免疫应答规律),还为抗病毒药物的筛选和预防性疫苗的研发提供了更有效的技术途径。介绍了目前大家熟知的动物模型,包括黑猩猩模型、树鼩模型、小鼠模型等,并对各种模型的优势与缺陷进行了分析。近年来HCV感染小动物模型,尤其是转基因小鼠模型的建立,为HCV感染动物模型开创了新领域,是动物模型研究的热点和重点。Abstract: An animal model of hepatitis C virus(HCV) infection involves the use of an animal to build the model for simulating the whole process of HCV infection in humans.Establishing an ideal animal model for HCV infection is conducive to study on the pathogenesis of chronic hepatitis C,including virus-host interactions,viral variability,and host immune response patterns.Additionally,it provides a more effective technical strategy for screening antiviral drugs and developing preventive vaccines.This article summarizes well-known animal models of HCV infection,such as those established in chimpanzees,tree shrews,and mice.The advantages and drawbacks of each kind of animal models are analyzed.In recent years,the establishment of small animal models,particularly those in transgenic mice,has opened up a new field in the development of animal models of HCV infection,which will be the hotspot and emphasis of relevant animal model studies.
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Key words:
- hepacivirus /
- model,animal /
- infection /
- review
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