Relationship between intestinal microflora imbalance and nonalcoholic fatty liver disease
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摘要: 肠道微生态系统由定植于肠道的固有菌群、肠上皮细胞、肠黏膜免疫系统组成。非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感性相关的代谢应激性肝损伤。近年来关于肠道微生态与NAFLD发病机制关系的研究越来越多。肠道微生态失衡导致的肠道菌群过度生长、肠黏膜通透性增加、肠源性内毒素血症、炎症因子产生等在NAFLD的发生发展过程中扮演着重要的角色。深入研究肠道微生态失衡与NAFLD的关系将有助于为NAFLD的治疗及预防提供新方向。Abstract: The intestinal microecosystem is composed of natural microflora,intestinal epithelial cells,and intestinal mucosal immune system.Nonalcoholic fatty liver disease(NAFLD) is a metabolic stress-induced liver injury associated with insulin resistance and genetic susceptibility.In recent years,there has been increasing evidence showing the involvement of imbalanced intestinal microflora in the pathogenesis of NAFLD.Overgrowth of intestinal microflora,increased permeability of intestinal mucosa,intestinal endotoxemia,and production of inflammatory cytokines play important roles in the development of NAFLD.Further studies on the relationship between intestinal microflora imbalance and the pathogenesis of NAFLD may shed light on the treatment and prevention of NAFLD.
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Key words:
- intestinal microflora /
- fatty liver /
- endotoxemia /
- inflammation /
- review
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