Correlation between clinical data and pathological stage in patients with primary biliary cirrhosis: a study of 54 cases
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摘要:
目的探讨原发性胆汁性肝硬化(PBC)患者肝脏病理分期与临床指标间的相关性,以指导临床诊断与治疗。方法收集2011年1月至2013年9月北京佑安医院收治的54例PBC患者的临床资料,分析其临床指标与病理分期的相关性。临床指标检测包括生化学指标、免疫学指标及自身抗体,并采用肝穿刺活组织病理检查进行病理分期。正态分布的计量资料组间比较采用方差分析;偏态分布计量资料组间比较采用Wilcoxon秩和检验;计数资料用行×列χ2检验;相关性分析采用Pearson及Logistic回归法。结果 54例PBC患者以中年女性为主,男∶女为1∶5,平均(48.9±9.3)岁;病理分期:Ⅰ期15例,Ⅱ期18例,Ⅲ期12例,Ⅳ期9例,Ⅳ期患者年龄大于其他病理分期,差异有统计学意义(P<0.05);TBil、ALP、凝血酶原时间(PT)、Ig A、Ig G、SP100与病理分期呈正相关(r值分别为0.592、0.343、0.281、0.388、0.274、0.320,P值均<0.05),而Alb与病理分期呈负相关(r=-0.569,P=0.000)。多因素分析TBil水平与PBC患者病理分期呈独立相关...
Abstract:Objective To investigate the correlation between clinical data and pathological stage in patients with primary biliary cirrhosis( PBC) and to provide guidance for clinical diagnosis and treatment. Methods The clinical data of 54 PBC patients were collected for analyzing the correlation between the clinical data and pathological stage. The clinical data included biochemical parameters,immunological markers,and autoantibodies. Biopsy of the liver was used for the pathological staging of PBC. For the continuous data of normal distribution,analysis of variance was applied for comparisons between groups; for continuous data of skewed distribution,Wilcoxon rank sum test was used. For categorical data,chi- square test was used. Correlation analysis was performed by Pearson correlation and logistic regression. Results Among the 54 patients,the male- to- female ratio was 1∶ 5; the mean age was 48. 9 ± 9. 3 years; pathological stage Ⅰ was identified in 15 cases,stage Ⅱ in 18 cases,stage Ⅲ in 12 cases,and stage Ⅳ in 9 cases,and patients with stage Ⅳ disease were significantly older than the other patients( P < 0. 05). Total bilirubin( TBil),alkaline phosphatase,prothrombin time,Ig A,Ig G,and SP200 were positively correlated with pathological stage( r = 0. 592,0. 343,0. 281,0. 388,0. 274,and 0. 320,respectively,P < 0. 05),while a negative correlation was found between albumin and pathological stage( r =- 0. 569,P = 0. 000). Multivariate analysis revealed an independent correlation between TBil level and pathological stage( P = 0. 039). Patients with the same pathological stage might have different clinical stages,while those with the same clinical stage might have different pathological stages. Conclusions The same pathological stage may appear in different clinical stages. TBil level is an independent predictive factor for pathological stage in PBC patients.
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Key words:
- liver cirrhosis,biliary /
- autoantibodies /
- biopsy /
- pathology,clinical
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