Efficacy of thymosin α1 in chronic HBV infection patients with low viral load in immune-clearance or low-replication phase
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摘要:
目的观察胸腺肽α1治疗低病毒载量慢性HBV感染的疗效。方法随机选取2011年6月-2013年6月诊治的低病毒载量慢性HBV感染者76例为治疗组,41例为对照组。治疗组给予胸腺肽α11.6mg,皮下注射,每周2次,治疗3个月HBVDNA阴性者可停药,阳性者治疗至6个月;对照组不进行药物治疗。观察3、6个月时HBVDNA转阴情况。组间比较计量资料采用t检验,计数资料采用χ2检验。结果治疗3、6个月时治疗组HBVDNA转阴率显著高于对照组(χ2值分别为10.61、13.09,P值均<0.01)。治疗6个月时,治疗组HBVDNA<104拷贝 2="0.02,P">0.05),但显著高于HBVDNA≥104拷贝/ml者(χ2=7.52,P<0.01)。结论胸腺肽α1能显著促进低病毒载量慢性HBV感染者HBVDNA转阴,转阴率与DNA载量呈负相关,与HBeAg状态无关。
Abstract:Objective To study the efficacy of thymosin α1 in the treatment of chronic hepatitis B virus( HBV) infection with low viral load. Method Seventy- six patients with low- viral load chronic HBV infection admitted to our hospital from June 2011 to June 2013 were randomly assigned to treatment group,and forty- one patients were assigned to control group. The treatment group received subcutaneous injection of 1. 6 mg thymosin α1 twice a week,and the treatment stopped at 3 months if the patients were negative for serum HBV DNA; otherwise,the treatment was extended to 6 months. The control group did not receive any treatment. The serum HBV DNA clearance rates at months 3 and 6 of treatment were measured in both groups. Comparison of continuous data between two groups was made by t test,and comparison of categorical data was made by χ2test. Results The treatment group showed significantly higher HBV DNA clearance rates than the control group at months 3 and 6 of treatment( χ2= 10. 61,P < 0. 01; χ2= 13. 09,P < 0. 01). At month 6 in the treatment group,the HBV DNA clearance rate in patients who had HBV DNA < 104 copies / ml and were positive for HBe Ag showed no significant difference from that in those who were negative for HBe Ag( χ2= 0. 02,P > 0. 05),but was significantly higher than that in patients with HBV DNA ≥104copies / ml( χ2= 7. 52,P < 0. 01). Conclusion Thymosin α1 significantly promotes HBV DNA clearance in patients with low- viral load chronic HBV infection. The clearance rate is negatively correlated with the DNA load,but shows no correlation with the HBe Ag status.
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Key words:
- hepatitis B virus /
- viral load /
- infection /
- thymosin αlpha-1
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