Study on pathogenesis of schistosomal liver fibrosis
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摘要: 血吸虫病引起的重要病理特征是肝纤维化,主要由于血吸虫虫卵释放可溶性虫卵抗原形成虫卵肉芽肿,刺激机体产生炎症反应,进而引起细胞外基质过量沉积而致,与肝星状细胞、T细胞及其他细胞因子密切相关。对于血吸虫病肝纤维化的细胞和调解分子机制的深入认识,将有助于发现更多的药物作用靶点,用于新药研发,指导临床治疗,给血吸虫病患者肝纤维化治疗带来新希望。Abstract: The important pathological feature induced by schistosomiasis is liver fibrosis. Schistosome eggs release soluble egg antigen to form egg granuloma,which stimulates host inflammation,induces extracellular matrix deposition,and finally causes liver fibrosis. This process is tightly associated with hepatic stellate cells,T cells,and other cytokines. Deep understanding of cellular and molecular mechanisms of schistosomiasis- induced liver fibrosis will help to identify targets for drug development and clinical treatment,and bring new hope to patients with schistosomiasis- induced liver fibrosis.
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Key words:
- schistosomiasis /
- liver cirrhosis /
- cytokines
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