Clock drawing test in cognitive assessment for patients with hepatitis B cirrhosis
-
摘要: 目的探讨画钟测验(CDT)用于肝硬化患者认知功能评估的意义及其可能的影响因素。方法收集2012年6月至2012年12月于首都医科大学附属北京地坛医院门诊就诊的Child-Turcotte-Pugh(CTP)分级为A级的乙型肝炎肝硬化患者(肝硬化组)以及健康志愿者(对照组)各95例,CDT分别对两组进行认知功能测验及相关因素的问卷调查。正态分布计量资料的组间比较采用t检验,非正态分布计量资料组间比较采用秩和检验,计数资料组间比较χ2检验,CDT得分的相关因素分析采用Spearman秩相关分析。结果本组乙型肝炎肝硬化患者的自发画钟(CDT-1)与模仿画钟(CDT-2)总分的中位数分别17和26,对照组的得分分别为20和27,经秩和检验显示肝硬化组患者的CDT-1总分、CDT-1与CDT-2的数字及指针部分得分均低于对照组(P值均<0.05),而在锚定部分得分及CDT-2总分方面的差异无统计学意义(P>0.05);Spearman相关分析显示,健康对照组的CDT-2的总分与年龄呈负相关关系(r=-0.262,P<0.05),与驾驶史呈正相关关系(r=0.238,P<0...Abstract: Objective To explore the significance and potential influencing factors for the clock drawing test( CDT) in cognitive assessment for patients with hepatitis B cirrhosis. Methods Ninety- five Child- Turcotte- Pugh class A patients with hepatitis B cirrhosis,who were admitted to our hospital from June to December,2012,were enrolled as subjects. Ninety- five healthy volunteers were used as controls.CDT was conducted in the two groups to measure cognitive functions and investigate potential influencing factors. Results The medians of total scores of CDT1 and CDT2 were 17 and 26,respectively,in patients with hepatitis B cirrhosis,and 20 and 27,respectively,in the control group. The rank- sum test showed that the total score of CDT1 and the scores of the digital and pointer parts in CDT1 and CDT2 were all significantly lower in the cirrhosis group than in the control group( P < 0. 05). There were no significant differences in the total score of CDT2 and the scores of the anchor parts in CDT1 and CDT2 between the two groups. The Spearman correlation analysis indicated that the total score of CDT2 was negatively correlated with age( r =- 0. 262,P < 0. 05) and positively correlated with driving history( r = 0. 238,P <0. 05) in the control group; in the cirrhosis group,the total score of CDT1 was negatively correlated with abnormal direct bilirubin level( r =- 0. 203,P < 0. 05),and the total score of CDT2 was positively correlated with education,driving history,and antiviral therapy( r =0. 291,P < 0. 05; r = 0. 222,P < 0. 05; r = 0. 223,P < 0. 05). Conclusion The impairment in visual- spatial ability of patients with hepatitis B cirrhosis should be taken into account. CDT is helpful for the early detection of cognitive dysfunction in patients with cirrhosis.
-
Key words:
- hepatitis B /
- liver cirrhosis /
- clock drawing test /
- cognition
本文二维码
计量
- 文章访问数: 1982
- HTML全文浏览量: 15
- PDF下载量: 480
- 被引次数: 0