Roles of epithelial cell adhesion molecule in diagnosis and treatment of hepatocellular carcinoma
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摘要: 上皮细胞黏附分子(Ep CAM)为一种跨膜糖蛋白,表达于上皮组织和多数上皮源性恶性肿瘤中,与细胞的黏附、迁移、增殖、分化以及肿瘤的发生、进展等有关。近年来,Ep CAM被认为是肝细胞癌(HCC)干细胞标志物,阐述了其在HCC诊断、治疗及预后判定中的作用,认为其可能为未来的分子靶向治疗提供线索。Abstract: Epithelial cellular adhesion molecule( Ep CAM) is a transmembrane glycoprotein expressed in epithelial tissues and most epithelial- derived malignant tumors. Ep CAM is associated with cell adhesion,migration,proliferation,and differentiation,as well as tumor development and progression. In recent years,Ep CAM has been identified as a stem cell marker of hepatocellular carcinoma( HCC). This paper elucidates the roles of Ep CAM in the diagnosis,treatment,and prognosis of HCC,which shed light on the potential molecular targeted therapy in future.
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Key words:
- carcinoma,hepatocellular /
- epithelial cell /
- cell adhesion molecules /
- diagnosis /
- therapy /
- review
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