Surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus
-
摘要: 门静脉癌栓(PVTT)是肝细胞癌(简称肝癌)重要的生物学特性,也是其严重并发症和转移方式,手术切除仍然是目前肝癌伴PVTT最有效的治疗方法。介绍了肝癌伴PVTT手术治疗的历史与现状、PVTT形成的解剖学基础、PVTT分型、手术适应证、术式选择以及手术疗效评价。认为在循证医学的基础上建立个体化多学科治疗模式,可能是肝癌伴PVTT治疗的发展方向。Abstract: Portal vein tumor thrombus( PVTT) is one of the important biological characteristics of hepatocellular carcinoma( HCC),and also a serious complication and a metastatic mode. Surgical treatment is still the most effective therapy for HCC with PVTT. This article describes the history and present situation of surgical treatment of HCC with PVTT,the anatomical basis for PVTT formation,classification of PVTT,indications for surgery,selection of surgical approaches,and evaluation of the surgical outcome of PVTT. Individualized multidisciplinary treatment should be developed based on evidence- based medicine,which might be the right direction for the treatment of HCC with PVTT.
-
[1]LEE NW,WONG J,ONG GB.The surgical management of primary carcinoma of the liver[J].World J Surg,1982,6(1):66-75. [2]LIN TY,LEE CS,CHEN KM,et al.Role of surgery in the treatment of primary carcinoma of the liver:a 31-year experience[J].Br J Surg,1987,74(9):839-842. [3]KUMADA K,OZAWA K,OKAMOTO R,et al.Hepatic resection for advanced hepatocellular carcinoma with removal of portal vein tumor thrombi[J].Surgery,1990,108(5):821-827. [4]YAMAOKA Y,KUMADA K,INO K,et al.Liver resection for hepatocellular carcinoma(HCC)with direct removal of tumor thrombi in the main portal vein[J].World J Surg,1992,16(6):1172-1176. [5]SHI J,LAI EC,LI N,et al.Surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus[J].Ann Surg Oncol,2010,17(8):2073-2080. [6]ZIMMERMAN MA,GHOBRIAL RM,TONG MJ,et al.Recurrence of hepatocellular carcinoma following liver transplantation:a review of preoperative and postoperative prognostic indicators[J].Arch Surg,2008,143(2):182-188. [7]MAZZAFERRO V,REGALIA E,DOCI R,et al.Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis[J].N Engl J Med,1996,334(11):693-699. [8]MARSH JW,DVORCHIK I,BONHAM CA,et al.Is the pathologic TNM staging system for patients with hepatoma predictive of outcome?[J].Cancer,2000,88(3):538-543. [9]YAO FY,FERRELL L,BASS NM,et al.Liver transplantation for hepatocellular carcinoma:comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria[J].Liver Transpl,2002,8(9):765-774. [10]Liver Cancer Study Group of Japan.The general rules for the clinical and pathological study of primary liver cancer[M].Second english edition,Tokyo:Kanehara&Co,Ltd,2003:17-20. [11]SHUQUN C,MENGCHAO W,HAN C,et al.Tumor thrombus types influence the prognosis of hepatocellular carcinoma with the tumor thrombi in the portal vein[J].Hepatogastroenterology,2007,54(74):499-502. [12]TOYOSAKA A,OKAMOTO E,MITSUNOBU M,et al.Pathologic and radiographic studies of intrahepatic metastasis in hepatocellular carcinoma;the role of efferent vessels[J].HPB Surg,1996,10(2):97-103. [13]OKUDA K,OHTSUKI T,OBATA H,et al.Natural history of hepatocellular carcinoma and prognosis in relation to treatment[J].Cancer,1985,56(4):918-928. [14]The Cancer of the Liver Italian Program(CLIP)Investigators.A new prognostic system for hepatocellular carcinoma:a retrospective study of 435 patients[J].Hepatology,1998,28(3):751-755. [15]WONG VW,CHAN SL,MO F,et al.Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers[J].J Clin Oncol,2010,28(10):1660-1665. [16]FORNER A,REIG ME,de LOPE CR,et al.Current strategy for staging and treatment:the BCLC update and future prospects[J].Semin Liver Dis,2010,30(1):61-74. [17]YAU T,TANG VY,YAO TJ,et al.Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma[J].Gastroenterology,2014,146(7):1691-1700. [18]MINAGAWA M,IKAI I,MATSUYAMA Y,et al.Staging of hepatocellular carcinoma:assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan[J].Ann Surg,2007,245(6):909-922. [19]EDGE SB,ed.Liver[M]//AJCC Cancer Staging Manual.7th Edn.New York:Springer,2009:201-210. [20]IKAI I,ITAI Y,OKITA K,et al.Report of the 15th follow-up survey of primary liver cancer[J].Hepatol Res,2004,28(1):21-29. [21] SHI J,LAI EC,LI N,et al.A new classification for hepatocellular carcinoma with portal vein tumor thrombus[J].J Hepatobiliary Pancreat Sci,2011,18(1):74-80. [22] KUDO M,IZUMI N,KOKUDO N,et al.Management of hepatocellular carcinoma in Japan:consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology(JSH)2010 updated version[J].Dig Dis,2011,29(3):339-364. [23]NCCN Clinical Practice Guidelines in Oncology.Hepatobiliary Cancer.V2.2014[EB/OL].[2015-01-13].WWW.nccn.org [24]ZENG ZP,XU ZQ,ZHOU CC,et al.Efficacy of autogenous peritoneo-fascial patch graft in reparing portal vein[J].Chin J Dig Surg,2013,12(2):145-146.(in Chinese)曾志平,徐宗全,周存才,等.自体腹膜修补门静脉的临床疗效[J].中华消化外科杂志,2013,12(2):145-146. [25]CHOK KH,CHEUNG TT,CHAN SC,et al.Surgical outcomes in hepatocellular carcinoma patients with portal vein tumor thrombosis[J].World J Surg,2014,38(2):490-496. [26]CHEN XP,QIU FZ,WU ZD,et al.Effects of location and extension of portal vein tumor thrombus on long-term outcomes of surgical treatment for hepatocellular carcinoma[J].Ann Surg Oncol,2006,13(7):940-946. [27]IKAI I,HATANO E,HASEGAWA S,et al.Prognostic index for patients with hepatocellular carcinoma combined with tumor thrombosis in the major portal vein[J].J Am Coll Surg,2006,202(3):431-438. [28]MATONO R,YOSHIYA S,MOTOMURA T,et al.Factors linked to long term survival of patients with hepatocellular carcinoma accompanied by tumour thrombus in the major portal vein after surgical resection[J].HPB(Oxford),2012,14(4):247-253. [29]BAN D,SHIMADA K,YAMAMOTO Y,et al.Efficacy of a hepatectomy and a tumor thrombectomy for hepatocellular carcinoma with tumor thrombus extending to the main portal vein[J].J Gastrointest Surg,2009,13(11):1921-1928. [30]KATAGIRI S,YAMAMOTO M.Multidisciplinary treatments for hepatocellular carcinoma with major portal vein tumor thrombus[J].Surg Today,2014,44(2):219-226.(in Chinese)
本文二维码
计量
- 文章访问数: 2848
- HTML全文浏览量: 22
- PDF下载量: 599
- 被引次数: 0