Clinical efficacy and problems of artificial liver support system in treatment of liver failure
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摘要:
肝衰竭是多种肝脏疾病发展到终末期的共同病理过程,由于发病机制复杂、缺乏有效的特异性治疗,其发病率和病死率仍然较高。目前,肝衰竭的治疗原则是以病因治疗、内科治疗、积极预防和控制并发症为主的综合治疗,包括非生物型、生物型和混合型人工肝技术在内的多种类型人工肝支持系统,可以有效清除毒素、补充有益必需物质和改善内环境,部分替代衰竭肝脏的功能,已经成为各种急、慢性肝衰竭治疗的重要手段而被广泛应用于临床,虽然人工肝技术的临床研究已经取得了较大进展,但同时也面临着许多亟待解决的问题。对人工肝治疗肝衰竭的作用、临床应用现状、存在问题及研究进展作一综述。
Abstract:Liver failure is a common pathophysiological process of various hepatic diseases developing into the end stage. Because of its intricate pathogenesis and lack of specific and impactful treatment,the incidence and mortality of hepatic failure remains high and life-threatening. Currently,the principle of therapy for liver failure includes eliminating the causes,medical treatment,and preventing complications.Various artificial liver support systems( ALSSs),such as non-bioartificial liver,bioartificial liver,and hybrid artificial liver,which can remove circulating toxins,provide essential substances,and improve the internal environment,act as a partial substitute of the liver and has been widely used as an important therapy for acute or chronic liver failure. Although substantial progress has been made in the clinical studies of ALSS,there are still many problems to be dealt with. This article reviews the clinical efficacy of ALSS,as well as current clinical application,existing problems,and research advances.
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Key words:
- liver failure /
- liver,artificial /
- therapy
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