Mechanism of treatment of acute-on-chronic liver failure with mesenchyaml stem cells
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摘要:
我国是肝病大国,当肝病发展至终末期时,肝移植成为治疗的最有效手段,但由于供体缺乏等原因,限制了慢加急性肝衰竭的治疗。而干细胞,特别是间充质干细胞治疗可在一定程度上改善肝损伤,并已运用于临床治疗,经过多年研究其治疗机制尚未完全阐明,由于其长期临床疗效不足,使其在临床应用上也有一定争议性。重点回顾了国内外近年相关文献,探讨间充质干细胞治疗慢加急性肝衰竭相关机制,以期选择最佳的临床方案。
Abstract:Liver diseases are common in China. When the diseases progress to the end stage,liver transplantation has been considered as the most effective means of treatment. Whereas,due to the causes such as lack of donors,the treatment of acute-on-chronic liver failure has been restricted. While stem cells,especially the mesenchymal stem cells,can improve liver damage to a certain extent and have been adopted in clinical treatment. After years of studies,the mechanism of treatment has not been thoroughly clarified; due to the insufficient long-term clinical efficacy,there is also controversy on the clinical application. This article reviews related literature at home and abroad in recent years to discuss the mechanism related to the treatment of acute-on-chronic liver failure with mesenchymal stem cells and indicate the optimal clinical protocol.
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Key words:
- liver failure /
- mesenchymal stem cells /
- therapy /
- review
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