Association between smoking and risk of primary biliary cirrhosis: a meta-analysis
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摘要:
目的从循证医学角度系统评价吸烟与原发性胆汁性肝硬化(PBC)发病的相关性。方法计算机检索Pub Med、Embsae、中国生物医学文献服务系统、中国知网、万方、维普数据库。中文检索词包括吸烟、香烟、原发性胆汁性肝硬化、危险因素、队列研究、病例对照研究,英文检索词包括smoking、cigarette、tobacco、risk factors、primary biliary cirrhosis、cohort studies、case-control studies。查找20多年来吸烟与PBC发病风险相关的病例对照研究,采用Rev Man 5.2软件进行Meta分析,计算其比值比(OR)和95%可信区间(95%CI)并对发表偏倚进行漏斗图分析。结果纳入7个病例对照研究,共5459例,其中PBC患者2562例。Meta分析结果显示,吸烟人群与不吸烟人群比较,其患PBC的风险增加(OR=1.49,95%CI:1.112.00,P=0.009)。按地域进行亚组分析,结果显示北美洲人群的OR为1.57,95%CI:1.202.04,P=0.000 8,吸...
Abstract:Objective To systematically evaluate the association between smoking and the risk of primary biliary cirrhosis( PBC) from the perspective of evidence- based medicine. Methods A literature search was performed in Pub Med,EMBASE,CBM,CNKI,Wanfang Data,and VIP database to collect the case- control studies on the association between smoking and the risk of PBC published in the last two decades. Chinese search words were “吸烟”,“香烟”,“原发性胆汁性肝硬化”,“危险因素”,“队列研究”,and “病例对照研究”,and English search words were “smoking”,“cigarette”,“tobacco”,“risk factors”,“primary biliary cirrhosis”,“cohort studies”,and“case- control studies”. And then a meta- analysis was performed using Review Manager 5. 2. The pooled odds ratio( OR) and 95% confidence interval( CI) were calculated,and the publication bias was analyzed by funnel plots. Results A total of 7 case- control studies involving 5459 subjects( 2652 patients with PBC vs 2807 controls) were included in the meta- analysis. The analysis results showed that smokers had a significantly higher risk of PBC compared with non- smokers( OR = 1. 49,95% CI: 1. 11- 2. 00,P = 0. 009). The geographical subgroup analysis results showed that there was a significant difference in the risk of PBC between non- smokers and smokers in North America( OR = 1. 57,95% CI: 1. 20- 2. 04,P = 0. 0008). However,there was no significant difference in the risk of PBC between non- smokers and smokers in Europe( OR = 1. 41,95% CI: 0. 73- 2. 73,P = 0. 31). Conclusion Smoking can increase the risk of PBC. However,it needs to be confirmed in high- quality prospective studies with larger samples because of the heterogeneity of current included studies.
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Key words:
- liver cirrhosis,biliary /
- smoking /
- Meta-analysis
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