Relationship between serum HBsAg level and liver histological features in chronic HBV infection patients with low ALT levels
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摘要:
目的通过分析低ALT水平慢性HBV感染者血清HBs Ag水平与肝组织炎症分级及纤维化分期的关系,探讨影响肝组织学的相关因素。方法收集2010年1月-2013年12月在广东省人民医院就诊的慢性HBV感染者511例,检测肝组织学、血清HBs Ag定量、HBV DNA定量。正态分布的计量资料两组间比较采用t检验,非正态分布的资料多组间比较采用Kruskal-Wallis H检验,进一步两两比较采用Nemeny检验。计数资料组间比较采用χ2检验,采用Spearman等级相关分析法判断HBs Ag水平与肝组织炎症分级和纤维化分期的相关性。结果 511例患者有不同程度肝组织异常。年龄≥40岁组HBe Ag阳性率、HBs Ag定量、HBV DNA定量均低于年龄<40岁组,差异均有统计学意义(统计值分别为86.80、2.99、7.25,P值分别为<0.000 1、0.003、0.000 1)。不同年龄组肝组织炎症分级和纤维化分期的分布差异有统计学意义(χ2值分别为70.03、61.92,P值均<0.000 1)。Spearman等级相关分析结果显示,HBe Ag阳性和HBe Ag阴性...
Abstract:Objective To investigate the factors influencing the liver histological features in chronic hepatitis B virus( HBV) infection patients with low alanine transaminase( ALT) levels by analyzing the relationship of serum hepatitis B surface antigen( HBs Ag) level with liver inflammation grade and fibrosis stage. Methods A total of 511 HBV infection patients admitted to our hospital from December 2010 to December 2013 were studied. The liver histological features,serum HBs Ag level,and HBV DNA copy number were examined. Comparison of categorical data between different groups was made by chi- square test,comparison of continuous data following the normal distribution was made by t test,and comparison of continuous data not following the normal distribution was made by Kruskal- Wallis H test. The relationship of serum HBs Ag level with liver inflammation grade and fibrosis stage was determined by Spearman's rank correlation analysis. Results All patients showed different degrees of hepatic histological abnormalities. The group aged more than or equal to 40 years had significantly lower HBe Ag positive rate,HBs Ag level,and HBV DNA copy number compared with the group aged less than 40 years( χ2= 86. 8,P <0. 000 1; t = 2. 99,P = 0. 003; t = 7. 25,P < 0. 000 1). The groups with different ages had significant differences in liver inflammation grade and fibrosis stage( χ2= 70. 03,P < 0. 000 1; χ2= 61. 92,P < 0. 000 1). The Spearman's rank correlation analysis indicated that in both HBe Ag- positive and- negative patients HBs Ag level was negatively correlated with liver inflammation grade( r =- 0. 245,P < 0. 000 1;r =- 1. 51,P = 0. 019) and fibrosis stage( r =- 0. 153,P = 0. 012; r =- 0. 181,P = 0. 005). Conclusion Age is one of the important factors influencing the liver histological progression in chronic HBV infection patients with low ALT levels. HBs Ag level is negatively correlated with liver inflammation grade and fibrosis stage in chronic HBV infection patients with low ALT levels,so it could be used as an important non- invasive indicator for the liver histological status in these patients.
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Key words:
- hepatitis B,chronic /
- hepatitis B surface antigens /
- alanine transaminase /
- histology
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