Objective To investigate the association between different hepatitis C virus( HCV) genotypes and serum interleukin-17( IL-17),interleukin-6( IL-6),and vitamin D in patients with HCV-related cirrhosis. Methods Seventy-six patients with HCV-related cirrhosis,who were admitted to 302 Hospital of PLA from January to December,2012,were enrolled in the study,and they were divided into type 1b group( n = 47) and type 2a group( n = 29) according to the genotypes. The levels of serum IL-17,IL-6,and vitamin D were determined by enzyme-linked immunosorbent assay. Comparison between the two groups was made by t test,and Spearman correlation analysis was used to investigate the association between serum IL-17,IL-6,and vitamin D and genotypes. Results The findings in improved Child-Pugh classification showed that there were significant differences in the percentage of grade A patients between type 1b group and type 2a group( χ2= 4. 97,P < 0. 05); when compared with type 2a group,type 1b group showed significantly higher lentiviral titers of alpha-fetoprotein( AFP) and HCV RNA and levels of IL-17,IL-6,and tumor necrosis factor-α( TNFα)( t = 21. 56,16. 51,12. 31,10. 71,and 7. 23,respectively,all P < 0. 05),but significantly lower levels of interferon-γ( IFNγ),25( OH) D,and 1,25( OH)2D( t =3. 98,6. 32,and 4. 88,respectively; all P < 0. 05); Spearman correlation analysis showed that the lentiviral titers of AFP and HCV RNA and the levels of IL-17 and IL-6 were positively correlated with genotype 1b and genotype 2a( all P < 0. 05),while the levels of IFNγ,TNFα,and 25-OH-D were negatively correlated with genotype 1b and genotype 2a( all P < 0. 05). Conclusion Compared with those with genotype 2a,HCV-related cirrhosis patients with genotype 1b have higher serum levels of IL-17,IL-6,AFP,and HCV RNA,but a lower level of vitamin D; the results suggested that there are correlations between serum IL-17,IL-6,25-OH-D,AFP,and HCV RNA and genotype,but no significant correlation between 1,25( OH)2D and genotype.