前列腺素E1辅助治疗轻中度急性胰腺炎的临床分析

纪柏; 陈丽宇; 刘亚辉

doi:10.3969/j.issn.1001-5256.2016.01.023

前列腺素E1辅助治疗轻中度急性胰腺炎的临床分析

DOI: 10.3969/j.issn.1001-5256.2016.01.023

吉林大学第一医院肝胆胰外二科

基金项目:

横向合作资助项目；

详细信息

中图分类号: R576
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出版历程
- 收稿日期: 2015-07-01
- 出版日期: 2016-01-20

Efficacy of prostaglandin E1 as adjuvant therapy for mild to moderate acute pancreatitis

Second Department of Hepatobiliary and Pancreatic Surgery,The First Hospital of Jilin University

Research funding:

摘要

摘要: 目的对比观察前列腺素E1在治疗急性胰腺炎（AP）中的临床疗效和安全性。方法前瞻性研究2014年5月-2015年1月吉林大学第一医院收治的轻中度AP患者80例,随机分为2组。对照组44例行胰腺炎常规综合治疗,试验组36例在常规治疗基础上加用前列腺素E1。比较2组患者腹部症状消失时间、血尿淀粉酶、血清脂肪酶、C反应蛋白、降钙素原降至正常水平的时间。计量资料组间比较采用独立样本t检验;计数资料组间比较采用χ2检验或Fisher精确检验。结果 2组血淀粉酶、C反应蛋白、中性粒细胞百分比恢复正常值的时间及住院费用间差异均有统计学意义（P值分别为0.041、0.030、0.012、0.026）。前列腺素E1可明显加速缓解腹痛、腹胀,快速降低血淀粉酶、C反应蛋白和中性粒细胞百分比;缩短住院时间,减少住院费用。结论前列腺素E1在治疗胰腺炎中具有良好的临床疗效、安全性好,可作为胰腺炎药物综合治疗的辅助用药选择。
- 胰腺炎 /
- 前列腺素E类 /
- 治疗
Abstract: Objective To observe the clinical effect and efficacy of prostaglandin E1( PGE1),the drug for microcirculation improvement,in the treatment of acute pancreatitis( AP). Methods A total of 80 patients with mild- to- moderate AP who were hospitalized and treated in Second Department of Hepatobiliary and Pancreatic Surgery of the First Hospital of Jilin University from May 2014 to January 2015 were enrolled and randomized into two groups. Forty- four patients in control group received the conventional comprehensive therapy for AP,and36 patients in experiment group received PGE1 in addition to the conventional therapy. The time to disappearance of abdominal symptoms and the time for serum and urine levels of amylase and serum levels of lipase,C- reactive protein( CRP),and procalcitonin( PCT) to return to normal were compared between the two groups. The independent- samples t- test was applied for comparison of continuous data between the two groups,and the chi- square test or Fisher's exact test was applied for comparison of categorical data between the two groups.Results The two groups had significant differences in the time for serum levels of amylase and CRP and percentage of neutrophils to return to normal and hospital costs( P = 0. 041,0. 030,0. 012,and 0. 026,respectively). PGE1 quickly relieved abdominal pain and distention,reduced the serum level of amylase,shortened the length of hospital stay,and reduced hospital costs. Conclusion PGE1 has good clinical effect and safety in the treatment of AP,and can be applied as an adjuvant drug in the comprehensive therapy for AP.
- pancreatitis /
- prostaglandins E /
- therapy

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参考文献(15)

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