异甘草酸镁注射液与注射用还原型谷胱甘肽配伍的稳定性分析

李晓晖; 文娱; 晋文慧; 洪专; 曾美燕; 陈伟珠

doi:10.3969/j.issn.1001-5256.2016.01.028

异甘草酸镁注射液与注射用还原型谷胱甘肽配伍的稳定性分析

DOI: 10.3969/j.issn.1001-5256.2016.01.028

1. 厦门市中医院药物临床试验机构
2. 厦门市中医院药剂科
3. 国家海洋局第三海洋研究所

基金项目:

福建中医药大学2014年校管课题(XB2014050)；

详细信息

中图分类号: R969.2
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出版历程
- 收稿日期: 2015-05-07
- 出版日期: 2016-01-20

Compatible stability of magnesium isoglycyrrhizinate injection and reduced glutathione for injection

Drug Clinical Trial Institution,Xiamen Hospital of Traditional Chinese Medicine

Research funding:

摘要

摘要:
目的考察异甘草酸镁(MgIG)注射液与注射用还原型谷胱甘肽(GSH)在室温条件下配伍的稳定性。方法采用高效液相色谱法测定MgIG注射液与注射用GSH在5%、10%葡萄糖溶液中配伍的浓度变化。结果 MgIG注射液与注射用GSH配伍液在0、0.5、1、1.5、2、4 h内浓度均无明显变化。结论 MgIG注射液与注射用GSH在5%、10%葡萄糖溶液中可以配伍使用,但应在4 h内用完。
- 异甘草酸镁 /
- 谷胱甘肽 /
- 中药配伍 /
- 药物稳定性
Abstract:
Objective To evaluate the compatible stability of magnesium isoglycyrrhizinate( MgIG) injection and reduced glutathione( GSH) for injection at room temperature. Methods High- performance liquid chromatography was applied to measure the changes in the content of MgIG and reduced GSH after MgIG injection and reduced GSH for injection were mixed with 5% or 10% glucose solution. Results There were no significant changes in the content of MgIG and reduced GSH within 0,0. 5,1,1. 5,2,and 4 h after MgIG injection and reduced GSH for injection were mixed with 5% or 10% glucose solution. Conclusion MgIG injection and reduced GSH for injection are compatible in 5% and 10% glucose solutions,but the mixed solution should be used within 4 h.
- magnesium isoglycyrrhizinate /
- glutathione /
- compatibility /
- drug stability

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参考文献(11)

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