肝血窦在内毒素致肝损伤中的作用

赵利利; 袁东亚; 孙芳云

doi:10.3969/j.issn.1001-5256.2016.01.040

肝血窦在内毒素致肝损伤中的作用

DOI: 10.3969/j.issn.1001-5256.2016.01.040

西藏民族大学医学院生命科学基础研究实验室

基金项目:

2014年西藏自治区科技厅自然科学基金项目；

详细信息

中图分类号: R575
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- 被引次数: 0
出版历程
- 收稿日期: 2015-06-04
- 出版日期: 2016-01-20

Role of hepatic sinusoids in lipopolysaccharide-induced liver injury

Lab for Basic Research of Life Science,Xizang Minzu University

Research funding:

摘要

摘要: 内毒素是革兰阴性菌细胞壁中的特有成分,又称脂多糖(LPS)。肝脏既是清除细菌和内毒素的场所,又是最易受损的器官。肝损伤最初发生在肝血窦。主要介绍了LPS对Kupffer细胞、肝窦内皮细胞、肝血窦中氧化/抗氧化平衡及肝脏血流的影响。认为肝血窦在LPS所造成的肝损伤中的作用不容忽视,研究其对防治LPS致肝损伤有重要意义。
- 肝疾病 /
- 脂多糖类 /
- 枯否细胞 /
- 综述
Abstract: Endotoxin,which is also called lipopolysaccharide( LPS),is a unique element of Gram- negative bacteria. Liver is the main site for removing bacteria and endotoxin. Meanwhile,it is also the most vulnerable organ. Liver injury initially occurs in the hepatic sinusoids. This article mainly introduces the impact of LPS on Kupffer cells,hepatic sinusoidal endothelial cells,oxidant / antioxidant balance in the hepatic sinusoids,and liver blood flow. It is believed that the function of hepatic sinusoids in LPS- induced liver injury should not be ignored,and the hepatic sinusoids would play an important role in the prevention and treatment of LPS- induced liver injury.
- liver diseases /
- lipopolysaccharides /
- kupffer cells /
- review

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参考文献(31)

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