Research advances in innate immunity against hepatitis B virus
-
摘要: HBV入侵人体时,天然免疫首先发挥重要的作用。成人感染HBV后,常常会被自发清除,然而在出生或者年幼时期感染HBV时,病情更容易慢性化并且迁延终生。在HBV感染初期,天然免疫应答对病毒复制的抑制发挥了重要作用,HBV感染的转归取决于宿主和病毒共同作用。简述了近年来有关HBV与宿主天然免疫中发挥重要作用的细胞类型、细胞因子、信号通路及其作用机制的研究进展,并指出了其在临床治疗方面的潜在价值。Abstract: When hepatitis B virus( HBV) invades the human body,innate immunity acts the earliest and plays an important role. When an adult is infected with HBV,HBV can often be eliminated spontaneously. However,if HBV infection occurs right after birth or when the patient is young,the disease tends to become chronic and affect the whole life. In the incipient stage of HBV infection,innate immune response plays an important role in inhibiting viral replication,and the prognosis of HBV infection depends on the combined effect of host and virus. This article briefly introduces the research advances in the cells,cytokines,and signaling pathways that play important roles in the host's innate immunity against HBV and their mechanisms of action,and points out their potential values in clinical treatment.
-
Key words:
- hepatitis B virus /
- immunity,natural /
- review
-
[1]SCHWEITZER A,HORN J,MIKOLAJCZYK RT,et al.Estimation of worldwide prevalence of chronic hepatitis B virus infection:a systematic review of data published between 1965 and 2013[J].Lancet,2015,386(10003):1546-1555. [2]GENEVA.Guidlines for the prevention,care and treatment of persons with CHB infection[S/OL].2015,WHO,PMID:26225396.http://www.ncbi.nlm.nih.gov/pubmed/26226396. [3]BUSCA A,KUMAR A.Innate immune responses in hepatitis B virus(HBV)infection[J].Virol J,2014,11:22. [4]STEFAN F,FRANCIS V.Stealth and cunning:hepatitis B and hepatitis C viruses[J].Virol J,2005,79(15):9369-9380. [5]ZHENG Q,ZHU YY,CHEN J,et al.Activated natural killer cells accelerate liver damage in patients with chronic hepatitis B virus infection[J].Clin Exp Immunol,2015,180(3):499-508. [6]FISICARO P,VALDATTA C,BONI C,et al.Early kinetics of innate and adaptive immune responses during hepatitis B virus infection[J].Gut,2009,58(7):974-982. [7]JU Y,HOU N,MENG J,et al.T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3)mediates natural killer cell suppression in chronic hepatitis B[J].J Hepatol,2010,52(3):322-329. [8]FERRARI C.HBV and the immune response[J].Liver Int,2015,35(Suppl 1):121-128. [9]DUNN C,PEPPA D,KHANNA P,et al.Temporal analysis of early immune responses in patients with acute hepatitis B virus infection[J].Gastroenterology,2009,137(4):1289-1300. [10]HEIBERG IL,PALLETT LJ,WINTHER TN,et al.Defective natural killer cell anti-viral capacity in paediatric HBV infection[J].Clin Exp Immunol,2015,179(3):466-476. [11]EBERT G,PRESTON S,ALLISON C,et al.Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus[J].Proc Natl Acad Sci U S A,2015,112(18):5797-5802. [12]XIA Y,STADLER D,LUCIFORA J,et al.Interferon-γand tumor necrosis factor-αproduced by T cells reduce the HBV persistence form,cccD NA,without cytolysis[J].Gastroenterology,2016,150(1):194-205. [13]BENGSCH B,MARTIN B,THIMME R.Restoratin of HBV-specific CD8+T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentation[J].J Hepatol,2014,61(6):1212-1219. [14]PROTZER U,MAINI MK,KNOLLE PA.Living in the liver:hepatic infections[J].Nat Rev Immunol,2012,12(3):201-213. [15]BOLTJES A,MOVITA D,BOONSTRA A,et al.The role of kupffer cells in hepatitis B and hepatitis C virus infections[J].J Hepatol,2014,61(3):660-671. [16]MOVITA D,KREEFFT K,BIESTA P,et al.Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages[J].J Leukoc Biol,2012,92(4):723-733. [17]YUE X,WANG H,ZHAO F,et al.Hepatitis B virus-induced calreticulin protein is involved in IFN resistance[J].J Immunol,2012,189(1):279-286. [18]DUNN C,BRUNETTO M,REYNOLDS G,et al.Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage[J].J Exp Med,2007,204(3):667-680. [19]PURO R,SCHNEIDER RJ.Tumor necrosis factor activates a conserved innate antiviral response to hepatitis B virus that destabilizes nucleocapsids and reduces nuclear viral DNA[J].J Virol,2007,81(14):7351-7362. [20]CHEN QY,LIU YH,LI JH,et al.DNA dependent activator of interferon-regulatory factors inhibits hepatitis B virus replication[J].World J Gastroenterol,2012,18(22):2850-2858. [21]HAN Q,ZHANG C,ZHANG J,et al.Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition[J].PLoS One,2011,6(12):e27931. [22]GUO F,HAN Y,ZHAO X,et al.STING agonists induce antiviral immune response against hepatitias B virus[J].Antimicrob Agents Chemother,2015,59(2):1273-1281. [23]YUEN MF,LAI CL.Hepatitis B in 2014:HBV research moves forward—receptors and reactivation[J].Nat Rev Gastroenterol Hepatol,2015,12(2):70-72. [24]MOHAMADKHANI A,POURDADASH A,TAYEBI S,et al.The potential role of APOBEC3G in limiting replication of hepatitis B virus[J].Arab J Gastroenterol,2012,13(4):170-173. [25]SONG ZW,MA YX,FU BQ,et al.Altered mRNA levels of MOV10,A3G,and IFN-αin patients with chronic hepatitis B[J].J Microbiol,2014,52(6):510-514. [26]GUO H,JIANG D,MA D,et al.Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells[J].J Virol,2009,83(2):847-858. [27]XIONG W,WANG X,LIU X,et al.Interferon-inducible MyD 88 protein inhibits hepatitis B virus replication[J].Virology,2004,319(2):306-314. [28]HONG Y,ZHOU L,XIE H,et al.Innate immune evasion by hepatitis B virus-mediated downregulation of TRIF[J].Biochem Biophys Res Commun,2015,463(4):719-725. [29]AYOOBI F,HASSANSHAHI G,ZAINODINI N,et al.Reduced expression of TRIF in chronic HBV infected Iranian patients[J].Clin Res Hepatol Gastroenterol,2013,37(5):491-495. [30]KAISER WJ,OFFERMANN MK.Apoptosis induced by the tolllike receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif[J].J Immunol,2005,174(8):4942-4952. [31]ZHANG YY,HU KQ.Rethinking the pathogenesis of hepatitis B virus(HBV)infection[J].J Med Virol,2015,87(12):1989-1999. [32]DONG ZJ,WEI HM,SUN R,et al.Involvement of natural killer cells in PolyⅠ:C-induced liver injury[J].J Hepatol,2004,41(6):966-973. [33]BOLTJES A,van MONTFOORT N,BIESTA PJ,et al.Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro,leading to proinflammatory cytokine production and natrue killer cell function[J].J Infect Dis,2015,211(8):1268-1278.
本文二维码
计量
- 文章访问数: 1482
- HTML全文浏览量: 20
- PDF下载量: 430
- 被引次数: 0