New immunotherapeutic strategies for chronic hepatitis B
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摘要: 慢性乙型肝炎(CHB)是全球重要的传染病之一,目前主要的治疗药物为干扰素与核苷和核苷酸类药物,具有较好疗效,但尚未达到彻底清除人体内HBV的最终目标。因此,探索治疗新策略以及研发新的治疗药物有重要意义。HBV的持续感染与机体内免疫状态密切相关,目前研究表明免疫治疗有助于实现彻底治愈CHB。结合CHB患者的免疫状态,综述了Toll样受体激动剂、细胞治疗、治疗性疫苗等免疫治疗新策略的研究进展。Abstract: Chronic hepatitis B( CHB) is one of the most important infectious diseases around the world. Currently,interferon and nucleos( t) ide analogues are the main drugs for CHB and have good therapeutic efficacy,but the ultimate goal of eliminating hepatitis B virus( HBV) in human body has not been achieved. Therefore,it is of vital importance to explore new therapeutic strategies and develop new drugs for CHB. Persistent HBV infection is closely associated with human body's immune status,and studies have shown that immunotherapy may help to cure CHB. With reference to CHB patients' immune status,this article reviews the research advances in new immunotherapeutic strategies including Toll- like receptor agonists,cell therapy,and therapeutic vaccines.
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Key words:
- hepatitis B /
- chronic /
- immunotherapy
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