Biochemical parameters in diagnosis of cholestatic liver disease
-
摘要: 尽管近年来国内外相继发布有关"胆汁淤积性肝病"诊疗指南及专家共识,但关于胆汁淤积诊断的生化标准还存在很多问题,比如不同原因引起的胆汁淤积有各自的诊断标准,差异很大。这给临床医生带来很大困扰,也不利于相关科研的进行。就胆汁淤积相关的常见指标进行了分析,并指出了当前诊断中存在的问题。建议相关组织进一步深入讨论并规范关于胆汁淤积诊断的生化指标,为深入开展胆汁淤积的临床和科研工作提供更可靠的依据。Abstract: Although guidelines and expert consensuses have been published on the diagnosis and treatment of cholestatic liver disease recently in China and the rest of the world,many problems still exist in the biochemical standard for the diagnosis of cholestasis; for example,there are substantially different diagnostic criteria for cholestasis of various causes. This brings confusion to clinical doctors and is not good for research. This article analyzes common parameters in cholestasis and points out the problems in diagnosis. It is recommended to organize in- depth discussions and set standard for the diagnosis of cholestasis,in order to provide a more reliable basis for clinical research on cholestasis.
-
Key words:
- cholestasis /
- diagnosis /
- biological markers
-
[1]Expert Committee on the 2015 update of expert consensus on the diagnosis and treatment of cholestatic liver disease.Expert consensus on the diagnosis and treatment of cholestatic liver disease:an update in 2015[J].J Clin Hepatol,2015,31(10):1563-1574.(in Chinese)胆汁淤积性肝病诊断治疗专家共识2015年更新专家委员会.胆汁淤积性肝病诊断治疗专家共识:2015年更新[J].临床肝胆病杂志,2015,31(10):1563-1574. [2]Chinese Expert Committee on the Diagnosis and Treatment of Cholestatic Liver Disease.Expert consensus on the diagnosis and treatment of cholestatic liver disease 2013[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition,2013,7(1):134-144.(in Chinese)胆汁淤积性肝病诊断治疗专家委员会.胆汁淤积性肝病诊断治疗专家共识2013[J/CD].中华实验和临床感染病杂志:电子版,2013,7(1):134-144. [3]Committee of Experts of Diagnosis and Treatment of Intrahepatic Cholestasis.Expert consensus for diagnosis and treatment of intrahepatic cholestasis[J].Chin J Clin Infect Dis,2015,8(5):402-406.(in Chinese)胆汁淤积症专家委员会.肝内胆汁淤积症诊治专家共识[J].中华临床感染病杂志,2015,8(5):402-406. [4]WU F,SUN FX.The value ofγ-glutamyl transpeptidase in the diagnosis and prognosis of liver diseases[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition,2015,9(5):9-13.(in Chinese)吴芳,孙凤霞.γ-谷氨酰转肽酶在肝脏疾病诊断和预后中的意义[J/CD].中华实验和临床感染病杂志:电子版,2015,9(5):9-13. [5]HUANG GJ,ZHU WD,LU ZP.Diagnosis and treatment of earlystage primary biliary cirrhosis[J].J Pract Hepatol,2012,15(4):356-357.(in Chinese)黄国进,祝卫东,陆志平.早期原发性胆汁性肝硬化诊治探讨[J].实用肝脏病杂志,2012,15(4):356-357. [6]Chinese Society of Infectious and Parasitic Diseases&Chinese Society of Liver Diseases,Chinese Medical Association.Diagnostic criteria for viral hepatitis[J].Chin J Integr Tradit West Med Liver Dis,2001,11(1):56-60.(in Chinese)中华医学会传染病与寄生虫病学分会、肝病学分会.病毒性肝炎的诊断标准[J].中西医结合肝病杂志,2001,11(1):56-60. [7]HAYASHI PH,FONTANA RJ.Clinical features,diagnosis,and natural history of drug-induced liver injury[J].Semin Liver Dis,2014,34(2):134-144. [8]Drug-induced Liver Disease Study Group,Chinese Society of Hepatology,Chinese Medical Association.Guidelines for the management of drug-induced liver injury[J].J Clin Hepatol,2015,31(11):1752-1769.(in Chinese)中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志,2015,31(11):1752-1769. [9]GEENES V,WlL LIAMSON C.Intrahepatic cholestasis of preg-nancy[J].World J Gastroenterol,2009,15(17):2049-2066. [10]Obstetrics Subgroup,Chinese Society of Obstetrics and Gynecology,Chinese Medical Association.Guidelines for the management of intrahepatic cholestasis of pregnancy(2015)[J].J Clin Hepatol,2015,31(10):1575-1578.(in Chinese)中华医学会妇产科学分会产科学组.妊娠期肝内胆汁淤积症诊疗指南(2015)[J].临床肝胆病杂志,2015,31(10):1575-1578.
本文二维码
计量
- 文章访问数: 2576
- HTML全文浏览量: 15
- PDF下载量: 566
- 被引次数: 0