Research advances in diagnosis and treatment of IgG4-associated autoimmune hepatitis
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摘要: 自身免疫性肝炎(AIH)是一种累及肝脏实质的慢性进展性炎症性疾病。近年来,对IgG4相关性疾病的研究日益增多,外国学者研究发现,AIH患者的肝脏亦有IgG4阳性浆细胞浸润,表明IgG4可能参与AIH的发病机制,进而认为这是AIH的特殊类型,称之为IgG4相关性AIH(IgG4-AIH)。对AIH与IgG4-AIH的诊治研究进展进行简要综述,从而加强临床医生对此类疾病的认知。Abstract: Autoimmune hepatitis( AIH) is a chronic progressive inflammatory disease involving the liver parenchyma. In recent years,there have been more studies focusing on IgG4- associated diseases. Foreign scholars have found that patients with AIH also have IgG4- positive plasma cell infiltration in the liver,suggesting that IgG4 may be involved in the pathogenesis of AIH,and this disease is considered a special type of AIH and thus it is called IgG4- associated AIH( IgG4- AIH). This article reviews the research advances in the diagnosis and treatment of AIH and IgG4- AIH,so as to enhance clinical doctors' knowledge of such diseases.
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Key words:
- hepatitis,autoimmune /
- immunoglobulin G /
- diagnosis /
- therapy /
- review
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