Advances in immunological treatment of autoimmune hepatitis
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摘要:
近年来自身免疫性肝炎(AIH)以其独特的临床和病理学特征,受到越来越多的关注。但目前其发病率和临床特征仍不十分清楚,尚需对其进行系统深入的研究。探讨了AIH的流行病学、病因和发病机制、临床特征及其诊断和治疗进展。指出TNFα中和性抗体、利妥昔单抗、全反式维甲酸和调节性T淋巴细胞移植在临床试验或AIH动物模型中均被证明对AIH有疗效。
Abstract:In recent years,autoimmune hepatitis( AIH) has attracted more and more attention due to its unique clinicopathological features. However,its incidence and clinical features remain unclear,and systematic and in-depth studies are still needed. This article reviews the epidemiology,etiology,pathogenesis,clinical features,and diagnosis and treatment of AIH and points out that clinical studies or animal models of AIH have proved the effects of TNF-α neutralizing antibody,rituximab,all-trans retinoic acid,and regulatory T cell transplantation in the treatment of AIH.
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Key words:
- hepatitis /
- autoimmune /
- immunology
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