Diagnosis and treatment of hepatitis B virus infection complicated by metabolic syndrome
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摘要:
随着肥胖在全球的流行,HBV感染合并代谢综合征(MS)的发病率逐年升高,成为慢性HBV感染者中的一类特殊人群,对其疾病特征、诊治策略的研究也是近年肝病领域的热点之一。MS不仅增加慢性乙型肝炎(CHB)患者肝纤维化和肝硬化的风险,还可降低抗病毒治疗的应答。因此对于HBV感染者,尤其是抗病毒治疗应答不佳的CHB患者,应考虑是否合并有MS及其组分;对HBV感染合并MS患者应积极进行肝硬化相关的筛查和监测,指导制订合适的治疗方案。
Abstract:With the prevalence of obesity around the world,the incidence rate of hepatitis B virus( HBV) infection complicated by metabolic syndrome( MS) is increasing year by year,and such patients have become a special population in patients with chronic HBV infection. In recent years,the research on the features of this disease and diagnosis and treatment strategies has become a hot topic in the field of liver disease. MS not only increases the risk of liver fibrosis and cirrhosis in chronic hepatitis B( CHB) patients,but also reduces the response to antiviral therapy. Therefore,as for patients with HBV infection,especially CHB patients with suboptimal response to antiviral therapy,MS and its components should be considered. Screening and monitoring of liver cirrhosis should be performed for patients with HBV infection complicated by MS to guide the development of proper treatment regimens.
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Key words:
- hepatitis B virus /
- metabolic syndrome /
- diagnosis /
- therapy
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