Value of serum cancer antigen12-5 level in diagnosis of peritoneal effusion in patients with liver cirrhosis
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摘要: 目的探讨血清CA12-5水平对肝硬化腹腔积液程度的诊断价值。方法收集2011年1月-2015年12月在首都医科大学附属北京天坛医院住院并且符合纳入标准的肝硬化患者142例。根据是否出现腹腔积液将所有患者分为腹腔积液组(n=81)和无腹腔积液组(n=61),符合正态分布的计量资料组间比较采用两独立样本t检验,不符合正态分布的采用Mann-Whitney U非参数检验,计数资料组间比较采用χ2检验。采用Spearman相关分析评估血清CA12-5水平与腹腔积液程度的相关性。结果腹腔积液组血清CA12-5水平显著高于无腹腔积液组[290.00(50.82618.40)U/ml vs 15.39(9.7723.04)U/ml,Z=-8.531,P<0.01]。血清CA12-5水平与腹腔积液程度呈正相关(r=0.812,P<0.01),且对腹腔积液具有较高的诊断价值(受试者工作特征曲线下面积为0.92)。当血清CA12-5取值为35.00 U/ml时具有最佳的敏感度和特异度,分别为81.5%和88.5%。结论血清CA12-5有助于肝硬化腹腔...Abstract: Objective To investigate the value of serum cancer antigen 12- 5( CA12- 5) level in the diagnosis of peritoneal effusion in patients with liver cirrhosis. Methods A total of 142 patients with liver cirrhosis who were hospitalized at Beijing Tiantan hospital from January 2011 to December 2015 and met the inclusion criteria were enrolled. According to the presence or absence of peritoneal effusion,the patients were divided into peritoneal effusion group( 81 patients) and non- peritoneal effusion group( 61 patients). The two- independent-samples t test was used for comparison of normally distributed continuous data between groups,the Mann- Whitney U non- parametric test was used for comparison of non- normally distributed continuous data between groups,and the chi- square test was used for comparison of categorical data between groups. A Spearman correlation analysis was used to investigate the correlation between serum CA12- 5 level and the degree of peritoneal effusion. Results The peritoneal effusion group had a significantly higher serum CA12- 5 level than the non- peritoneal effusion group [290. 00( 50. 82- 618. 4) U / ml vs 15. 39( 9. 77- 23. 04) U / ml,Z =- 8. 537,P < 0. 01]. Serum CA12- 5 level was positively correlated with the degree of peritoneal effusion( r = 0. 812,P < 0. 01) and had a high diagnostic value for peritoneal effusion( the area under the receiver operating characteristic curve was 0. 92). Serum CA12- 5 level had a sensitivity of 81. 5% and a specificity of 88. 5%at a cut- off value of 35. 00 U / ml. Conclusion Serum CA12- 5 level can help with the diagnosis and monitoring of peritoneal effusion.
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Key words:
- liver cirrosis /
- CA12-5 antigen /
- diagnosis
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