中国梦:没有乙型肝炎的未来

樊蓉; 尹雪如; 侯金林; 刘志华

doi:10.3969/j.issn.1001-5256.2017.01.002

中国梦:没有乙型肝炎的未来

DOI: 10.3969/j.issn.1001-5256.2017.01.002

南方医科大学南方医院肝病中心和感染内科

详细信息

中图分类号: R512.62;R183
计量
- 文章访问数: 399
- HTML全文浏览量: 68
- PDF下载量: 241
- 被引次数: 0
出版历程
- 收稿日期: 2016-11-29
- 出版日期: 2017-01-20

The Chinese dream: hepatitis B-free generation

Hepatology Unit and Department of Infectious Diseases,Nanfang Hospital,Southern Medical University

摘要

摘要:
HBV感染是我国最重要的公共卫生问题之一。阻断HBV母婴传播是消灭病毒性肝炎对我国人群危害的主要手段之一。最新研究结果证实了妊娠晚期使用替诺福韦酯抗病毒治疗可进一步减少HBV母婴传播。同时,中国肝炎防治基金会于2015年7月25日启动了"乙型肝炎母婴零传播工程"("小贝壳"项目),旨在通过移动医疗工具对乙型肝炎孕妇进行规范化管理,以达到进一步减少甚至消除HBV母婴传播的目的。目前我国抗击乙型肝炎已经取得了举世瞩目的成就,相信随着这项最新研究的发现以及"小贝壳"项目的启动,终将会实现没有乙型肝炎的未来。
- 肝炎病毒,乙型 /
- 疾病传播,垂直 /
- 述评
Abstract:
In China,hepatitis B virus( HBV) infection remains a great threat to public health. Preventing the mother- to- child transmission( MTCT) of HBV is the main method to reduce the harm and disease burden caused by viral hepatitis in China. Recent studies have demonstrated that antiviral therapy with tenofovir disoproxil fumarate( TDF) during late pregnancy for mothers can further reduce MTCT of HBV. Meanwhile,Chinese Foundation for Hepatitis Prevention and Control launched the Hepatitis B Shield Project on July 25,2015. This project aims to further reduce or even eliminate MTCT of HBV by means of standard management of pregnant women with HBV via a mobile- health application. At present,China has made great achievements in fighting against HBV. We believe that the remarkable findings of such studies and the launch of the Chinese Shield Project will make the Chinese dream- HBV- free generation come true in the near future.
- hepatitis B virus /
- disease transmission /
- vertical

HTML全文

参考文献(15)

[1]WANG FS,FAN JG,ZHANG Z,et al.The global burden of liver disease:the major impact of China[J].Hepatology,2014,60(6):2099-2108.

[2] Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B:a 2015 update[J].J Clin Hepatol,2015,31(12):1941-1960.(in Chinese)中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015年更新版)[J].临床肝胆病杂志,2015,31(12):1941-1960.

[3]World Health Organization.Tenofovir reduces mother-to-child transmission of hepatitis B:new study[EB/OL].[2016-06-16].http://www.who.int/hepatitis/news-events/hbv-mtcttenofovir/en/

[4]VISVANATHAN K,DUSHEIKO G,GILES M,et al.Managing HBV in pregnancy.Prevention,prophylaxis,treatment and follow-up:position paper produced by Australian,UK and New Zealand key opinion leaders[J].Gut,2016,65(2):340-350.

[5]ZOU H,CHEN Y,DUAN Z,et al.Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBs Ag-positive mothers[J].J Viral Hepat,2012,19(2):e18-e25.

[6]PAN CQ,HAN GR,JIANG HX,et al.Telbivudine prevents vertical transmission from HBe Ag-positive women with chronic hepatitis B[J].Clin Gastroenterol Hepatol,2012,10(5):520-526.

[7]CHEN HL,LEE CN,CHANG CH,et al.Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis B virus[J].Hepatology,2015,62(2):375-386.

[8]ZHANG H,PAN CQ,PANG Q,et al.Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice[J].Hepatology,2014,60(2):468-476.

[9] XU WM,CUI YT,WANG L,et al.Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection:a multicentre,randomized,double-blind,placebo-controlled study[J].J Viral Hepat,2009,16(2):94-103.

[10]GREENUP AJ,TAN PK,NGUYEN V,et al.Efficacy and safety of tenofovir disoproxil fumarate in pregnancy to prevent perinatal transmission of hepatitis B virus[J].J Hepatol,2014,61(3):502-507.

[11]HAN GR,CAO MK,ZHAO W,et al.A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection[J].JHepatol,2011,55(6):1215-1221.

[12]PAN CQ,DUAN Z,DAI E,et al.Tenofovir to prevent hepatitis Btransmission in mothers with high viral load[J].N Engl J Med,2016,374(24):2324-2334.

[13]FAN R,YIN X,HOU J.Prevention of peripartum hepatitis B transmission[J].N Engl J Med,2016,375(15):1496-1498.

[14]World Health Organization.Combating hepatitis B and C to reach elimination by 2030[EB/OL].[2016-05].http://apps.who.int/iris/bitstream/10665/206453/1/WHO_HIV_2016.04_eng.pdf

[15]FAN R,YIN X,LIU Z,et al.A hepatitis B-free generation in China:from dream to reality[J].Lancet Infect Dis,2016,16(10):1103-1105.

施引文献

资源附件(0)

访问统计