胰性脑病的诊治现状

张永国; 郭晓钟

doi:10.3969/j.issn.1001-5256.2017.01.009

胰性脑病的诊治现状

DOI: 10.3969/j.issn.1001-5256.2017.01.009

沈阳军区总医院消化内科

详细信息

中图分类号: R576;R747.9
计量
- 文章访问数: 2568
- HTML全文浏览量: 21
- PDF下载量: 464
- 被引次数: 0
出版历程
- 收稿日期: 2016-10-28
- 出版日期: 2017-01-20

Current status of diagnosis and treatment of pancreatic encephalopathy

Department of Gastroenterology,General Hospital of Shenyang Military Area Command

摘要

摘要: 胰性脑病(PE)是胰腺炎的严重并发症,早期诊断困难、预后差。介绍了胰酶激活、细胞因子、感染、水电解质紊乱、维生素缺乏等因素参与PE的可能发病机制。归纳了PE的临床表现和实验室检查特点,指出PE临床表现特异性不强,缺乏可靠的生化诊断指标,无明确的诊断标准。阐述了PE的诊治策略,指出PE的重点在于积极有效地治疗原发病,大部分PE患者随着胰腺炎病情的缓解而好转。
- 胰性脑病 /
- 诊断 /
- 治疗
Abstract: Pancreatic encephalopathy( PE) is a serious complication of pancreatitis,with difficulties in early diagnosis and poor prognosis.This article introduces the possible pathogenesis of PE involving pancreatin activation,cytokines,infection,water and electrolyte imbalance,and vitamin deficiency,summarizes the clinical manifestations and laboratory features of PE,and points out that the clinical manifestations of PE lack specificity and there are no reliable biochemical indices or diagnostic criteria. This article also elaborates on the diagnosis and treatment strategies for PE and points out that the key to PE treatment is active and effective treatment of the primary disease. Most PE patients are improved with the control of pancreatitis.
- pancreatic encephalopathy /
- diagnosis /
- therapy

HTML全文

参考文献(20)

[1]ROTHERMICH NO,von HAAM E.Pancreatic encephalopathy[J].J Clin Endocr,1941,1(4):872-881.

[2]ZHANG JP,NI JL.Research progress of pancreatic encephalopathy[J].J Hepatopancreatobiliary Surg,2011,23(5):439-440.(in Chinese)张建平,倪家连.胰性脑病诊治研究进展[J].肝胆胰外科杂志,2011,23(5):439-440.

[3]WANG Q,LI X.Research progress of pancreatic encephalopathy in SAP[J].Chin J Pract Surg,2004,24(1):63-64.(in Chinese)汪谦,李湘.SAP病人胰性脑病的研究进展[J].中国实用外科杂志,2004,24(1):63-64.

[4]MIAO Y,QIAN ZY.Diagnosis and treatment of pancreatic encephalopathy in SAP[J].J Hepatobiliary Surg,2005,13(1):6-8.(in Chinese)苗毅,钱祝银.重症急性胰腺炎胰性脑病的诊治[J].肝胆外科杂志,2005,13(1):6-8.

[5]ZHANG XP,TIAN H.Pathogenesis of pancreatic encephalopathy in severe acute pancreatitis[J].Hepatobiliary Pancreat Dis Int,2007,6(2):134-140.

[6]LIAO Z,LI ZS.Research progress of pancreatic encephalopathy[J].Chin J Pancreatol,2003,3(4):248-250.(in Chinese)廖专,李兆申.胰性脑病研究进展[J].中华胰腺病杂志,2003,3(4):248-250.

[7]ZHANG XP,TIAN H.Pathogenesis of pancreatic encephalopathy in severe acute pancreatitis[J].World Chin J Digestol,2005,13(22):2667-2671.(in Chinese)张喜平,田华.重症急性胰腺炎并发胰性脑病的发病机制[J].世界华人消化杂志,2005,13(22):2667-2671.

[8]KONG L.Pathogenesis and etiology of pancreatic encephalopathy[J].Chin J Curr Adv Gen Surg,2002,5(2):68-70.(in Chinese)孔雷.对胰性脑病病因和发病机制的认识[J].中国现代普通外科进展,2002,5(2):68-70.

[9]XU Z,WANG CY.Research progresss of pancreatic encephalopathy about its mechanism,diagnosis and treatment[J].Med Recapitulate,2007,13(14):1087-1089.(in Chinese)许州,王春友.胰性脑病发病机制及诊治研究进展[J].医学综述,2007,13(14):1087-1089.

[10]YIN BB,CAI D.Research progress of pancreatic encephalopathy[J].J Hepatopancreatobiliary Surg,2003,15(3):205-207.(in Chinese)殷保兵,蔡端.胰性脑病的诊治研究[J].肝胆胰外科杂志,2003,15(3):205-207.

[11]LU CL.Current research on pancreatic encephalopathy[J].Chin J Gen Surg,2001,10(4):362-365.(in Chinese)卢崇亮.胰性脑病的研究现状[J].中国普通外科杂志,2001,10(4):362-365.

[12]GUPTA R,DAS S,GUPTA R,et al.Altered sensorium in a chronic alcoholic:pancreatic encephalopathy,Wernicke's encephalopathy or Marchiafava Biganami disease?[J].Trop Gastroenterol,2015,36(4):266-268.

[13]SUN B,XU J,ZHOU ZQ,et al.Diagnosis and treatment of pancreatic encephalopathy in severe acute pancreatitis[J].J Harbin Med Univ,2003,37(5):437-438.(in Chinese)孙备,许军,周尊强,等.重症急性胰腺炎并发胰性脑病的诊断与治疗[J].哈尔滨医科大学学报,2003,37(5):437-438.

[14]CHEN LD,ZHANG XQ.Pancreatic encephalopathy and Wernicke's encephalopathy[J].Chin J Intern Med,2002,41(2):94-97.(in Chinese)陈隆典,张晓琦.胰性脑病与韦尼克脑病[J].中华内科杂志,2002,41(2):94-97.

[15]HORNIK A,RODRIGUEZ PORCEL FJ,AGHA C,et al.Central and extrapontine myelinolysis affecting the brain and spinal cord.An unusual presentation of pancreatic encephalopathy[J].Front Neurol,2012,3:135.

[16]OHKUBO T,SHIOJIRI T,MATSUNAGA T.Severe diffuse white matter lesions in a patient with pancreatic encephalopathy[J].J Neurol,2004,251(4):476-478.

[17]DING X,LIU CA,GONG JP,et al.Pancreatic encephalopathy in24 patients with severe acute pancreatitis[J].Hepatobiliary Pancreat Dis Int,2004,3(4):608-611.

[18]SUN GH,YANG YS,LIU QS,et al.Pancreatic encephalopathy and Wernicke encephalopathy in association with acute pancreatitis:a clinical study[J].World J Gastroenterol,2006,12(26):4224-4227.

[19]LU XS,QIU F,LI YX,et al.Effect of lower-molecular weight heparin in the prevention of pancreatic encephalopathy in the patient with severe acute pancreatitis[J].Pancreas,2010,39(4):516-519.

[20]QIU F,LU XS,HUANG YK.Protective effect of low-molecularweight heparin on pancreatic encephalopathy in severe acute pancreatic rats[J].Inflamm Res,2012,61(11):1203-1209.

施引文献

资源附件(0)

访问统计