中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

壳脂胶囊治疗非酒精性脂肪性肝炎的效果观察

宁惠明 欧强 黄玲 汤群

宁惠明, 欧强, 黄玲, 汤群. 壳脂胶囊治疗非酒精性脂肪性肝炎的效果观察[J]. 临床肝胆病杂志, 2017, 33(1): 137-140. DOI: 10.3969/j.issn.1001-5256.2017.01.030.
引用本文: 宁惠明, 欧强, 黄玲, 汤群. 壳脂胶囊治疗非酒精性脂肪性肝炎的效果观察[J]. 临床肝胆病杂志, 2017, 33(1): 137-140. DOI: 10.3969/j.issn.1001-5256.2017.01.030.
Ning HuiMing, Ou Qiang, Huang Ling, Tang Qun. Clinical effect of Kezhi capsules in treatment of nonalcoholic steatohepatitis[J]. J Clin Hepatol, 2017, 33(1): 137-140. DOI: 10.3969/j.issn.1001-5256.2017.01.030.
Citation: Ning HuiMing, Ou Qiang, Huang Ling, Tang Qun. Clinical effect of Kezhi capsules in treatment of nonalcoholic steatohepatitis[J]. J Clin Hepatol, 2017, 33(1): 137-140. DOI: 10.3969/j.issn.1001-5256.2017.01.030.

壳脂胶囊治疗非酒精性脂肪性肝炎的效果观察

DOI: 10.3969/j.issn.1001-5256.2017.01.030
详细信息
  • 中图分类号: R575

Clinical effect of Kezhi capsules in treatment of nonalcoholic steatohepatitis

  • 摘要:

    目的观察壳脂胶囊对非酒精性脂肪性肝炎的临床疗效及安全性。方法选取2013年11月-2015年12月于上海市第八人民医院就诊的非酒精性脂肪性肝炎(NASH)患者100例,随机分为治疗组、对照组各50例,分别予壳脂胶囊和多烯磷脂酰胆碱胶囊,疗程24周。观察两组治疗前后肝功能、血脂水平及肝/脾CT值的变化。计量资料组间比较采用两独立样本的t检验,组内比较采用配对样本t检验,计数资料组间比较采用χ2检验。结果两组患者治疗后AST[(49.2±21.7)U/L vs(119.5±44.2)U/L,t=10.0,P<0.01;(52.4±33.1)U/L vs(115.2±48.3)U/L,t=7.6,P<0.01]、ALT[(41.8±14.8)U/L vs(92.8±42.1)U/L,t=8.1,P<0.01;(42.9±16.6)U/L vs(95.3±40.4)U/L,t=8.5,P<0.01]、GGT[(52.3±23.7)U/L vs(168.4±85.9)U/L,t=9.2,P<0.01;(54.8±30.2)U/L vs(177.6±88.7)U/L,...

     

  • [1]FANELL CC,LATER CZ.Nonaleoholie fatty liver disease:from steatosis to cirrhosis[J].Hepatology,2006,43(2):99-112.
    [2]de ALWIS NM,DAY CP.NON-aleoholic fatty liver disease:the mist gradua Jly clears[J].J Hepatol,2008,48(Suppl 1):104-112.
    [3]Review Team,LABRECQUE DR,ABBAS Z,et al.World Gastroenterolopy Organiastion Global Guidelines:nonalcoholic fatty liver disease and nonalcoholic steatohepatitis[J].J Clin Gastroenterol,2014,48(6):467-473.
    [4]SCHERER A,DUFOUR JF.Treatment of non alcoholic fatty liver disease[J].Dig Dis,2016,34(Suppl 1):27-31.
    [5]The Chinese National Workshop on Fatty Liver and Alcoholic,Liver disease for the Chinese Liver Disease Association.Guidelines for the diagnosis and treatment of nonalcoholic fatty liver disease[J].J Clin Hepatol,2010,26(2):120-124.(in Chinese)中华医学会肝病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].临床肝胆病杂志,2010,26(2):120-124.
    [6]ROMBOMS K,MARRA F.Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis[J].Dig Dis,2010,28(1):229-235.
    [7]KUKLA M,CIUPINSKA-KAJOR M,KAJOR M,et al.Liver visfatin expression in morbidly obese patients with nonalcoholic fatty liver disease undrgoing bariatric surgery[J].Pol J Pathol,2010,61(3):147-153.
    [8]PAIS R,BARRITT AS,CALMUS Y,et al.NAFLD and liver transplantation:current burden and expected challenges[J].J Hepatol,2016,65(6):1245-1257.
    [9]DRAPKINA OM,DEEVA TA,VOLKOVA NP,et al.Current approaches to diagnosing and treating nonalcoholic fatty liver disease[J].Ter Arkh,2014,86(10):116-123.
    [10]MA JM,WANG JQ.Treatment of non-alcoholic fatty liver disease from deficiency[J].J Changchun Univ Tradit Chin Med,2014,30(5):850-852.(in Chinese)马菁蔓,王景朱.从虚论治非酒精性脂肪肝[J].长春中医药大学学报,2014,30(5):850-852.
    [11]WANG RB.Traditional Chinese medicine treatment of liver diseases[J].J Clin Hepatol,2015,31(1):2-6.(in Chinese)王融冰.肝病的中医药治疗[J].临床肝胆病杂志,2015,31(1):2-6.
    [12]ZHANG Y,XU SH.Pathogenic mechanism associated with insulin resistance and adiponectin abnormality in carotid atherosclerosis patients complicated with nonalcoholic fatty liver disease and their relationships with traditional Chinese medical syndrome types[J].J Guangzhou Univ Tradit Chin Med,2009,26(5):499-504.(in Chinese)张毅,徐尚华.颈动脉粥样硬化与非酒精性脂肪肝的胰岛素抵抗、脂联素异常相关机制及与中医证型关系分析[J].广州中医药大学学报,2009,26(5):499-504.
    [13]YANG YW,XIAO GM,ZHAO BM,et al.Randomized study of kezhi capsules in treating non-alcoholic fatty liver[J].The J Pract Med,2014,30(4):638-640.(in Chinese)杨跃武,肖阁敏,招柏明,等.壳脂胶囊治疗非酒精性脂肪肝的随机对照研究[J].实用医学杂志,2014,30(4):638-640.
    [14]WANG RQ,NAN YM,ZHAO SX,et al.Effects of Kezhi capsule on oxidative stress in mice with non-alcoholic steatohepatitis[J].Chin Hepatol,2011,16(3):216-219.(in Chinese)王荣琦,南月敏,赵素贤,等.壳脂胶囊对小鼠非酒精性脂肪性肝炎氧化应激的影响[J].肝脏,2011,16(3):216-219.
    [15]ZHAO WH,YU YQ,LIU LJ,et al.Experimental study of Kezhi capsule on PPAR-γand IR expression in non-alcoholic steatohepatitis rats[J].Chin J Integr Trad West Med Dig,2014,22(9):8-10.(in Chinese)赵唯含,余轶群,刘丽娟,等.壳脂胶囊对非酒精性脂肪性肝炎大鼠肝组织PPAR-γ、IR的作用研究[J].中国中西医结合消化杂志,2014,22(9):8-10.
  • 期刊类型引用(10)

    1. 隆晓荣,袁宁,陶然,曹杨港,胡锦,谭利婷,陈玮钰,毛德文. 中医药治疗非酒精性脂肪性肝病的研究进展. 中西医结合肝病杂志. 2023(09): 860-864 . 百度学术
    2. 郭一娇,周一康,胡明,杨男. 中成药治疗非酒精性脂肪性肝病临床综合评价. 中国药业. 2023(20): 130-135 . 百度学术
    3. 范文,郑垂仰,周旋,孔怡琳,潘丰满,杨钦河,张玉佩. 6种中成药治疗非酒精性脂肪性肝病有效性和安全性的网状Meta分析. 中药新药与临床药理. 2023(11): 1612-1622 . 百度学术
    4. 王超越,黄晓巍,王雨辰,林喆. 中药治疗非酒精性脂肪性肝病研究进展. 人参研究. 2022(05): 44-47 . 百度学术
    5. 何龙芳,龙云升. 探究在慢性乙肝的临床治疗中肝脂肪变对抗病毒治疗效果的影响情况. 智慧健康. 2021(06): 64-66 . 百度学术
    6. 薛黎霞. 疏肝降脂汤辅治非酒精性脂肪肝对肝功能及血脂水平的影响. 实用中医药杂志. 2021(06): 1035-1037 . 百度学术
    7. 张晓星,杨川,刘延东,王萌嘉,王丽哲. 保肝解毒汤灌肠治疗非酒精性脂肪性肝炎的效果. 中国卫生标准管理. 2020(13): 100-102 . 百度学术
    8. 梁栋,张鼎,仓宝成. 壳脂胶囊联合水飞蓟宾胶囊治疗非酒精性脂肪性肝病. 实用医药杂志. 2020(12): 1088-1089+1099 . 百度学术
    9. 王凤纤,李红纳. 复方甘草酸单铵与多烯磷脂酰胆碱联合治疗脂肪性肝炎的疗效观察. 云南医药. 2018(02): 166-169 . 百度学术
    10. 施懿凌,陆丽,罗永会. 脂肪肝的中医药治疗研究进展. 医学信息. 2018(24): 39-41 . 百度学术

    其他类型引用(14)

  • 加载中
计量
  • 文章访问数:  2460
  • HTML全文浏览量:  55
  • PDF下载量:  455
  • 被引次数: 24
出版历程
  • 出版日期:  2017-01-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回