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Immune tolerance after drug withdrawal in a patient with chronic hepatitis B receiving PEG- IFNα- 2a treatment
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摘要: <正>1病例资料患者男性,52岁。2014年2月初,因痔疮手术行常规检查发现:HBs Ag阳性,转氨酶升高,HBV DNA2.71×108拷贝/ml;肝抗原谱M2-3E阳性,余阴性;腹部CT:肝脏Ⅳ段小囊肿,右肾上极小囊肿。诊断"慢性乙型肝炎、原发性胆汁性肝硬化",开始服用恩替卡韦（ETV）、熊去氧胆酸治疗。为进一步明确诊断,2014年4月18日就诊于北京佑安医院。相关检查结果详见表1,特种蛋白系列、自身抗体系列、抗核
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Key words:
- hepatitis B,chronic /
- interferon alfa-2a /
- recurrence /
- immune tolerance /
- case reports
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[1]Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B:a 2015 update[J].J Clin Hepatol,2015,31(12):1941-1960.(in Chinese)中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015年更新版)[J].临床肝胆病杂志,2015,31(12):1941-1960. [2]PAN Y,WANG LN,SONG ZX,et al.Comparison of effects of entecavir and interferon therapy for HBe Ag-positive Chronic hepatitis B[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition,2016,10(4):392-395.(in Chinese)潘玉,王莉娜,宋正霞,等.恩替卡韦与干扰素治疗HBe Ag阳性慢性乙型肝炎的疗效[J/CD].中华实验和临床感染病杂志:电子版,2016,10(4):392-395. [3]CHEN XY,LIU YL.How patients with hepatitis B get really recovered[J].J Pract Hepatol,2016,19(3):257-260.(in Chinese)陈新月,柳雅立.慢性乙型肝炎患者如何获得临床治愈[J].实用肝脏病杂志,2016,19(3):257-260. [4]LI Q,ZHUO QB,HUANG YX,et al.Combination therapy and sequential therapy with interferons and nucleos(t)ide analogues against HBV[J].J Clin Hepatol,2015,31(4):495-499.(in Ghinese)李强,卓其斌,黄玉仙,等.干扰素与核苷和核苷酸类药物联合或序贯治疗慢性乙型肝炎方案的探讨[J].临床肝胆病杂志,2015,31(4):495-499. [5] WANG GL,MAO QG.A progress study on the treatment of chronic hepatitis B with interferon and nucleotide and nucleotide analogues in combination or sequential therapies[J].Med Inf,2014,27(1):460-462.(in Chinese)王国亮,毛乾国.干扰素与核苷(酸)类似物联合/序贯治疗慢性乙型肝炎研究进展[J].医学信息,2014,27(1):460-462. [6] DOU XG.Treatment strategies for patients with positive HBs Ag and normal ALT[EB/OL].(2015-10-31)[2016-07-11].http://www.ihepa.com:8088/pc/detail/14145?from=singlemessage&isappinstalled=1(in Chinese)窦晓光.HBs Ag阳性、ALT正常患者的处理策略[EB/OL].(2015-10-31)[2016-07-11].http://www.ihepa.com:8088/pc/detail/14145?from=singlemessage&isappinstalled=1 -
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