PIVKA-Ⅱ在肝细胞癌诊断及预后判断中的作用

李俊利; 尚佳; 宁会彬; 郭恩恩; 何佳

doi:10.3969/j.issn.1001-5256.2017.01.040

PIVKA-Ⅱ在肝细胞癌诊断及预后判断中的作用

DOI: 10.3969/j.issn.1001-5256.2017.01.040

郑州大学人民医院

基金项目:

河南省科技厅基础与前沿技术研究项目(142300410372)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2017-01-20

Role of serum abnormal prothrombin protein induced by vitamin K absence or antagonist-Ⅱ in development and progression of hepatocellular carcinoma

The People′s Hospital of Zhengzhou University, Zhengzhou 450000, China

Research funding:

摘要

摘要:
肿瘤标志物早期诊断对肝细胞癌（HCC）患者长期生存预后非常重要。阐述了血清异常凝血酶原维生素K缺乏或拮抗剂Ⅱ诱导的蛋白（PIVKA-Ⅱ）在HCC早期诊断、预后评估和复发预测中的价值,发现其敏感度和特异度较高,与AFP联合能明显提高HCC的早期诊断率。认为动态检测PIVKA-Ⅱ水平变化能够较好地协助临床正确评价HCC的发生、发展、浸润转移和复发,可以作为HCC预后的一个重要指标。
- 癌,肝细胞 /
- PIVKA-Ⅱ /
- 综述
Abstract:
Early diagnosis of hepatocellular carcinoma( HCC) using tumor markers is very important for long- term survival. This article elaborates on the value and high sensitivity and specificity of protein induced by vitamin K absence or antagonist- Ⅱ( PIVKA- Ⅱ) in the early diagnosis,prognostic evaluation,and recurrence prediction of HCC. Its combination with alpha- fetoprotein can significantly increase the early diagnostic rate of HCC. It is pointed out that dynamic measurement of PIVKA- Ⅱ level can assist the correct evaluation of the development,progression,invasion / metastasis,and recurrence of HCC and can be used as an important marker for the prognosis of HCC.
- carcinoma /
- hepatocellular /
- protein induced by vitamin K absence or antagonist Ⅱ

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参考文献(34)

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