射频消融治疗肝细胞癌的机制

王鹏; 任卫东

doi:10.3969/j.issn.1001-5256.2017.02.035

射频消融治疗肝细胞癌的机制

DOI: 10.3969/j.issn.1001-5256.2017.02.035

王鹏,
任卫东

中国医科大学附属盛京医院超声科

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2016-09-18
- 出版日期: 2017-02-20

Mechanism of radiofrequency ablation in treatment of hepatocellular carcinoma

Department of Ultrasound,Shengjing Hospital of China Medical University

摘要

摘要: 肝细胞癌(HCC)是一种世界范围内发病率和病死率均较高的恶性肿瘤,射频消融(RFA)是一种良好的治疗HCC的方法,尤其适用于肝癌术后复发患者、伴有肝功能不全且不能手术切除和某些多发肝癌患者姑息治疗等,可以明显提高患者的生存时间和生存质量,从直接损伤和间接损伤两个方面综述了RFA治疗HCC的机制,从而进一步理解RFA对肿瘤局部及全身的治疗作用,对今后HCC的多学科联合治疗有潜在价值。
- 肝肿瘤 /
- 癌,肝细胞 /
- 导管消融术 /
- 综述
Abstract: Hepatocellular carcinoma( HCC) is a malignant tumor with high incidence and mortality rates around the world.Radiofrequency ablation( RFA) is an effective therapy for HCC,especially in patients who experience recurrence after surgery for liver cancer,who are complicated by liver dysfunction and unable to undergo surgical resection,and who have multiple liver tumors and undergo palliative treatment.RFA can significantly improve patients' survival time and quality of life.This article reviews the mechanism of RFA in the treatment of HCC from the aspects of direct and indirect injuries and helps to further understand the role of RFA in local and systemic treatment of HCC,which has a potential value for multidisciplinary treatment of HCC in future.
- liver neoplasms /
- carcinoma /
- hepatocellular /
- catheter ablation

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参考文献(46)

[1]McG LYNN KA,PETRICK JL,LONDON WT.Global epidemiology of hepatocellular carcinoma:an emphasis on demographic and regional variability[J].Clin Liver Dis,2015,19(2):223-238.

[2]EL-SERAG HB.Epidemiology of viral hepatitis and hepatocellular carcinoma[J].Gastroenterology,2012,142(6):1264-1273.

[3]WONG R,FRENETTE C.Updates in the management of hepatocellular carcinoma[J].Gastroenterol Hepatol(NY),2011,7(1):16-24.

[4]FORNER A,LLOVET JM,BRUIX J.Hepatocellular carcinoma[J].Lancet,2012,379(9822):1245-1255.

[5]AKOAD ME,POMFRET EA.Surgical resection and liver transplantation for hepatocellular carcinoma[J].Clin Liver Dis,2015,19(2):381-399.

[6]Ministry of Health of the People's Republic of China.Diagnosis,management,and treatment of hepatocellular carcinoma(V2011)[J].J Clin Hepatol,2011,27(11):1141-1159.(in Chinese)中华人民共和国卫生部.原发性肝癌诊疗规范(2011年版)[J].临床肝胆病杂志,2011,27(11):1141-1159.

[7]ROSSI S.Percutaneous ultrasound-guided radiofrequency electrocautery for the treatment of small hepatocellular carcinoma[J].JIntervent Radiol,1993,8:97-103.

[8]LENCIONI R.Loco-regional treatment of hepatocellular carcinoma[J].Hepatology,2010,52(2):762-773.

[9]LIVRAGHI T,GOLDBERG SN,LAZZARONI S,et al.Small hepatocellular carcinoma:treatment with radio-frequency ablation versus ethanol injection[J].Radiology,1999,210(3):655-661.

[10]NIKFARJAM M,MALCONTENTI-WILSON C,CHRISTOPHI C.Focal hyperthermia produces progressive tumor necrosis independent of the initial thermal effects[J].J Gastrointest Surg,2005,9(3):410-417.

[11]MERTYNA P,HINES-PERALTA A,LIU Z,et al.Radiofrequency ablation:variability in heat sensitivity in tumors and tissues[J].J Vasc Interv Radiol,2007,18(5):647-654.

[12]CHU KF,DUPUY DE.Thermal ablation of tumours:biological mechanisms and advances in therapy[J].Nat Rev Cancer,2014,14(3):199-208.

[13]AHMED M,BRACE CL,LEE Jr FT,et al.Principles of and advances in percutaneous ablation[J].Radiology,2011,258(2):351-369.

[14]ZHOU Y,HAN G,WANG Y,et al.Radiofrequency heat-enhanced chemotherapy for breast cancer:towards interventional molecular image-guided chemotherapy[J].Theranostics,2014,4(11):1145.

[15]ZHANG F,LE T,WU X,et al.Intrabiliary RF heat-enhanced local chemotherapy of a cholangiocarcinoma cell line:monitoring with dualmodality imaging---preclinical study[J].Radiology,2014,270(2):400-408.

[16]DICKSON JA,CALDERWOOD SK.Temperature range and selective sensitivity of tumors to hyperthermia:a critical review[J].Ann N Y Acad Sci,1980,335(1):180-205.

[17]OVERGAARD K,OVERGAARD J.Investigations on the possibility of a thermic tumour therapy.I.Short-wave treatment of a transplanted isologous mouse mammary carcinoma[J].Eur J Cancer,1972,8(1):65-78.

[18]THOMSEN S.Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions[J].Photochem Photobiol,1991,53(6):825-835.

[19]OVERGAARD J,SUIT HD.Time-temperature relationship in hyperthermic treatment of malignant and normal tissue in vivo[J].Cancer Res,1979,39(8):3248-3253.

[20]MATTHEWSON K,COLERIDGE-SMITH P,O'SULLIVAN JP,et al.Biological effects of intrahepatic neodymium:yttrium-aluminum-garnet laser photocoagulation in rats[J].Gastroenterology,1987,93(3):550-557.

[21]van HILLEGERSBERG R,de WITTE MT,KORT WJ,et al.Water-jet-cooled Nd:YAG laser coagulation of experimental liver metastases:correlation between ultrasonography and histology[J].Lasers Surg Med,1993,13(3):332-343.

[22]YANG W,CUI M,LEE J,et al.Heat shock protein inhibitor,quercetin,as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism[J].Chin J Cancer Res,2016,28(1):19.

[23]FENG H,ZENG Y,WHITESELL L,et al.Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity[J].Blood,2001,97(11):3505-3512.

[24]MELCHER A,TODRYK S,HARDWICK N,et al.Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression[J].Nat Med,1998,4(5):581-587.

[25]LANNEAU D,BRUNET M,FRISAN E,et al.Heat shock proteins:essential proteins for apoptosis regulation[J].J Cell Mol Med,2008,12(3):743-761.

[26]CHALMIN F,LADOIRE S,MIGNOT G,et al.Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloidderived suppressor cells[J].J Clin Invest,2010,120(2):457-471.

[27]SPISEK R,CHARALAMBOUS A,MAZUMDER A,et al.Bortezomib enhances dendritic cell(DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells:therapeutic implications[J].Blood,2007,109(11):4839-4845.

[28]SCHUELLER G,KETTENBACH J,SEDIVY R,et al.Expression of heat shock proteins in human hepatocellular carcinoma after radiofrequency ablation in an animal model[J].Oncol Rep,2004,12(3):495-499.

[29]SCHUELLER G,KETTENBACH J,SEDIVY R,et al.Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo[J].Int J Oncol,2004,24(3):609-613.

[30]HAEN SP,GOUTTEFANGEAS C,SCHMIDT D,et al.Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation[J].Cell Stress Chaperones,2011,16(5):495-504.

[31]TSAN MF,GAO B.Heat shock proteins and immune system[J].JLeukoc Biol,2009,85(6):905-910.

[32]DUAN X,LI TF,ZHOU GF,et al.Transcatheter arterial embolization combined with radiofrequency ablation activates CD8+T-cell infiltration surrounding residual tumors in the rabbit VX2 liver tumors[J].Onco Targets Ther,2016,9:2835-2844.

[33]THIMME R,NEAGU M,BOETTLER T,et al.Comprehensive analysis of the alpha-fetoprotein-specific CD8+T cell responses in patients with hepatocellular carcinoma[J].Hepatology,2008,48(6):1821-1833.

[34]MIZUKOSHI E,YAMASHITA T,ARAI K,et al.Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma[J].Hepatology,2013,57(4):1448-1457.

[35]BEHM B,DI FAZIO P,MICHL P,et al.Additive antitumour response to the rabbit VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulation[J].Gut,2016,65(1):134-143.

[36]ZERBINI A,PILLI M,PENNA A,et al.Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses[J].Cancer Res,2006,66(2):1139-1146.

[37]ZERBINI A,PILLI M,FAGNONI F,et al.Increased immunostimulatory activity conferred to antigen-presenting cells by exposure to antigen extract from hepatocellular carcinoma after radiofrequency thermal ablation[J].J Immunother,2008,31(3):271-282.

[38]NOBUOKA D,MOTOMURA Y,SHIRAKAWA H,et al.Radiofrequency ablation for hepatocellular carcinoma induces glypican-3peptide-specific cytotoxic T lymphocytes[J].Int J Oncol,2012,40(1):63-70.

[39]de BETHLENFALVA-HORA CE,MERTENS JC,PIGUET AC,et al.Radiofrequency ablation suppresses distant tumour growth in a novel rat model of multifocal hepatocellular carcinoma[J].Clin Sci(Lond),2014,126(3):243-252.

[40]SHI L,CHEN L,WU C,et al.PD-1 blockade boosts radiofrequency ablation-elicited adaptive immune responses against tumor[J].Clin Cancer Res,2016,22(5):1173-1184.

[41]IKEMOTO T,SHIMADA M,YAMADA S.Pathophysiology of recurrent hepatocellular carcinoma after radiofrequency ablation[J].Hepatol Res,2017,47(1):23-30.

[42]ERINJERI JP,THOMAS CT,SAMOILIA A,et al.Image-guided thermal ablation of tumors increases the plasma level of interleukin-6 and interleukin-10[J].J Vasc Interv Radiol,2013,24(8):1105-1112.

[43]ROZENBLUM N,ZEIRA E,BULVIK B,et al.Radiofrequency ablation:inflammatory changes in the periablative zone can induce global organ effects,including liver regeneration[J].Radiology,2015,276(2):416-425.

[44]AHMED M,KUMAR G,MOUSSA M,et al.Hepatic radiofrequency ablation-induced stimulation of distant tumor growth is suppressed by c-Met inhibition[J].Radiology,2015,279(1):103-117.

[45]AHMED M,KUMAR G,NAVARRO G,et al.Systemic siRNAnanoparticle-based drugs combined with radiofrequency ablation for cancer therapy[J].PLoS One,2015,10(7):e0128910.

[46]YIN Y,NI CF,LI Z,et al.Therapeutic comparison between radiofrequency ablation and percutaneous ethanol injection in treatment of primary liver cancer:a meta-analysis[J].J Clin Hepatol,2015,31(6):918-921.(in Chinese)印于,倪才方,李智,等.射频消融与经皮无水乙醇注射治疗原发性肝癌疗效对比的Meta分析[J].临床肝胆病杂志,2015,31(6):918-921.

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