缺氧诱导因子1α异常表达对肝细胞癌血管生成的调控作用

王理; 施维; 薛均; 潘璀然; 姚敏; 姚登福

doi:10.3969/j.issn.1001-5256.2017.02.037

缺氧诱导因子1α异常表达对肝细胞癌血管生成的调控作用

DOI: 10.3969/j.issn.1001-5256.2017.02.037

1. 南通大学医学院
2. 南通大学附属医院

基金项目:

江苏省“六大人才高峰”(2013-WSN-011)；国家自然科学基金(81673241)；

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2016-09-26
- 出版日期: 2017-02-20

Regulatory effect of abnormal expression of hypoxia- inducible factor- 1α on angiogenesis in hepatocellular carcinoma

Medical School,Nantong University

Research funding:

摘要

摘要: 肝细胞癌是我国常见恶性肿瘤之一,伴有血供丰富,传统疗法易导致耐受,患者预后极差。肝组织缺氧诱导因子（HIF）1α与百余种下游靶基因的缺氧反应元件联合,参与血管新生、糖代谢等过程,从而抑制癌细胞分化和凋亡,促进癌细胞增殖。HIF-1α的高表达,以及对血管生成相关因子的调控,与肝癌患者放、化疗耐受,易浸润、转移及预后相关。综述了肝癌细胞HIF-1α异常表达对血管生成相关因子的调控作用和相互关系。
- 癌,肝细胞 /
- 缺氧诱导因子1 /
- 血管内皮生长因子类 /
- 血管生成素2 /
- 综述
Abstract: Hepatocellular carcinoma( HCC) is a common malignant tumor in China with abundant blood supply.Conventional therapies may easily cause tolerance and patients tend to have poor prognosis.Combined with the hypoxia response elements of over a hundred of downstream target genes,hypoxia- inducible factor- 1α( HIF- 1α) in liver tissue participates in many processes including angiogenesis and glucose metabolism,inhibits the differentiation and apoptosis of tumor cells,and promotes the proliferation of tumor cells.High expression of HIF- 1α and its regulatory effect on angiogenesis- related factors are closely associated with patients' tolerance to radiotherapy and chemoradiotherapy,tumor invasion,metastasis,and prognosis.This article reviews the regulatory effect of abnormal expression of HIF- 1α in HCC cells on angiogenesis- related factors and their interrelation.
- carcinoma /
- hepatocellular /
- hypoxia-inducible factor 1 /
- vascular endothelial growth factors /
- angiopoietin-2

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