酒精性肝病的遗传易感性研究现状

杨馥宁; 黄晶

doi:10.3969/j.issn.1001-5256.2017.02.039

酒精性肝病的遗传易感性研究现状

DOI: 10.3969/j.issn.1001-5256.2017.02.039

杨馥宁,
黄晶

吉林大学白求恩第一医院检验科

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2016-09-18
- 出版日期: 2017-02-20

Research progress in genetic susceptibility to alcoholic liver disease

Department of Clinical Laboratory,The First Hospital of Jilin University

摘要

摘要: 酒精性肝病(ALD)是临床上最常见的慢性肝脏疾病之一,其发病机制复杂。遗传因素在ALD的发病中具有重要作用,可能是潜在的ALD治疗靶点。综述了近年来与ALD相关的遗传易感基因,探索这些基因在ALD发生发展中的作用机制,可为临床有效评估、诊断以及防治ALD提供理论依据。
- 肝疾病,酒精性 /
- 疾病遗传易感性 /
- 多态性,单核苷酸 /
- 综述
Abstract: Alcoholic liver disease( ALD) is one of the most common chronic liver diseases in clinical practice with a complicated pathogenesis.Genetic factors play an important role in the pathogenesis of ALD and might be the potential targets for the treatment of ALD.This article reviews the susceptibility genes associated with ALD in recent years and points out that the exploration of the mechanisms of action of these genes in the development and progression of ALD can provide a theoretical basis for effective evaluation,diagnosis,and prevention and treatment of ALD in clinical practice.
- liver diseases /
- alcoholic /
- genetic predisposition to disease /
- polymorphism

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参考文献(33)

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