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肝纤维化的发病机制及治疗新靶点

张伟 贾继东

引用本文:
Citation:

肝纤维化的发病机制及治疗新靶点

DOI: 10.3969/j.issn.1001-5256.2017.03.001
详细信息
  • 中图分类号: R575.2

Pathogenesis and new therapeutic targets of liver fibrosis

  • 摘要: 近年来,肝纤维化的基础研究进展非常迅速。简单回顾了肝纤维化的细胞和分子发病机制,主要包括肌成纤维细胞的来源、免疫调节、自噬、表观调节。同时简要介绍了肝纤维化的几种治疗策略,为肝纤维化的治疗提供新的治疗靶点,分析表明祛除病因是目前最重要的抗肝纤维化治疗方法。尽管目前已经出现了针对不同靶点的抗纤维化药物,但大多数还处于早期研发阶段,尚需经过严格的临床研究才能确认其疗效。

     

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  • 收稿日期:  2017-01-04
  • 出版日期:  2017-03-20
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