肝窦内皮细胞在肝纤维化发生发展中的机制及相关治疗策略

杜艳芹; 吴珺; 杨东亮

doi:10.3969/j.issn.1001-5256.2017.03.008

肝窦内皮细胞在肝纤维化发生发展中的机制及相关治疗策略

DOI: 10.3969/j.issn.1001-5256.2017.03.008

华中科技大学同济医学院附属协和医院感染科

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中图分类号: R575.2
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出版历程
- 出版日期: 2017-03-20

Role of liver sinusoidal endothelial cells in the development and progression of liver fibrosis and related therapeutic strategy

Department of Infectious Diseases, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology

摘要

摘要: 肝窦内皮细胞不仅是保护肝脏免受损伤的第一道防线,也在慢性肝损伤导致的纤维化和肝硬化中伴有重要角色。它主要通过介导肝脏炎症反应、参与肝窦毛细血管化和血管再生、激活肝星状细胞、分泌多种促炎细胞因子、参与细胞外基质生成以及介导肝脏微循环障碍等参与肝纤维化。阐明这些机制,有助于探索肝纤维化治疗的新靶点和方案。
- 肝硬化 /
- 肝窦内皮细胞 /
- 治疗
Abstract: Liver sinusoid endothelial cells are the first defense mechanism that protects the liver against various injuries, and they also play a significant role in the development of liver fibrosis and liver cirrhosis caused by chronic liver injury.They are involved in liver fibrosis by mediating liver inflammation, participating in sinusoid capillarization and revascularization, activating hepatic stellate cells, secreting many proinflammatory cytokines, participating in extracellular matrix formation, and mediating liver microcirculation disturbance.Clarification of these mechanisms helps to identify new targets and develop new regimens for the treatment of liver fibrosis.
- liver cirrhosis /
- liver sinusoidal endothelial cells /
- therapy

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参考文献(51)

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