不同程度肝硬化门静脉血栓的临床特点及意义

聂巍; 林伟; 梁珊; 范作鹏; 仇丽霞; 刘义荣; 马丽霞; 韦新焕; 胡中杰; 张晶

doi:10.3969/j.issn.1001-5256.2017.03.015

不同程度肝硬化门静脉血栓的临床特点及意义

DOI: 10.3969/j.issn.1001-5256.2017.03.015

首都医科大学附属北京佑安医院丙肝与中毒性肝病科

基金项目:

艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2016ZX10004906);艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2016ZX10002007-006)；北京市朝阳区艾滋病和病毒性肝炎等重大传染病综合示范区建设研究(2012ZX10004-904)；丰台区科技新星计划项目；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2017-03-20

Clinical features of cirrhotic patients with different degrees of portal vein thrombosis and their clinical significance

Department of Hepatitis C & Toxic Liver Diseases, Beijing YouAn Hospital, Capital Medical University

Research funding:

摘要

摘要: 目的探讨不同严重程度门静脉血栓（PVT）肝硬化患者的肝功能及门静脉高压并发症的临床特点,明确PVT的临床意义。方法回顾性收集2014年1月-2015年6月首都医科大学附属北京佑安医院收治的肝硬化合并PVT患者178例,根据血栓严重程度分为单支血栓组（n=109）和多支血栓组（n=69）。记录患者的病因、临床表现、实验室结果及胃镜检查结果。符合正态分布的计量资料组间比较采用t检验,不符合正态分布的计量资料组间比较采用Wilcoxon秩和检验,计数资料组间比较采用χ2检验。结果单支血栓组中乙型肝炎肝硬化患者比例明显低于多支血栓组（50.5%vs 71.0%,χ2=7.350,P=0.008）,单支血栓组自身免疫性肝硬化比例明显高于多支血栓组（11.0%vs 0,χ2=8.145,P=0.004）;单支血栓组的PTA水平低于多支血栓组[（63.58±21.12）%vs（71.84±16.68）%,t=-2.701,P=0.008];单支血栓组食管静脉曲张重度比例显著低于多支血栓组（57.7%vs81.1%,χ2
- 肝硬化 /
- 静脉血栓形成 /
- 高血压,门静脉
Abstract: Objective To investigate liver function and clinical features of portal hypertension complications in cirrhotic patients with different degrees of PVT, and to clarify the clinical significance of PVT.Methods A retrospective analysis was performed for 178 cirrhotic patients with PVT who were admitted to Beijing You An Hospital, Capital Medical University, from January 2014 to June 2015, and according to the severity of thrombosis, they were divided into single thrombosis group (109 patients) and multiple thrombosis group (69 patients) .The etiology, clinical manifestation, laboratory results, and gastroscopic findings were recorded.The t-test was used for comparison of normally distributed continuous data, the Wilcoxon rank sum test was used for comparison of non-normally distributed continuous data between groups, and the chi-square test was used for comparison of categorical data between groups.Results Compared with the multiple thrombosis group, the single thrombosis group had a significantly lower proportion of patients with hepatitis B cirrhosis than the multiple thrombosis group (50.5% vs 71.0%, χ2=7.350, P=0.008) and a significantly higher proportion of patients with autoimmune cirrhosis (11.0% vs0, χ2=8.145, P=0.004) .Compared with the multiple thrombosis group, the single thrombosis group had significantly lower prothrombin time activity (63.58%±21.12% vs 71.84%±16.68%, t=-2.701, P=0.008) and significantly lower proportions of patients with severe esophageal varices (57.7% vs 81.1%, χ2=8.921, P=0.012) and red-color sign of esophageal varices (64.1% vs 86.8%, χ2=8.298, P=0.005) .Conclusion Multiple PVT does not influence patients' liver function, and patients with multiple PVT have marked esophageal varices compared with those with single PVT.
- liver cirrhosis /
- venous thrombosis /
- hypertension

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参考文献(14)

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