获得持续病毒学应答的慢性丙型肝炎患者发生肝细胞癌危险因素的研究进展

杨璐璇; 张新

doi:10.3969/j.issn.1001-5256.2017.03.033

获得持续病毒学应答的慢性丙型肝炎患者发生肝细胞癌危险因素的研究进展

DOI: 10.3969/j.issn.1001-5256.2017.03.033

杨璐璇,
张新

哈尔滨医科大学附属第一医院感染科

详细信息

中图分类号: R512.63;R735.7
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出版历程
- 收稿日期: 2016-10-17
- 出版日期: 2017-03-20

Research advances in risk factors for hepatocellular carcinoma in chronic hepatitis C patients with sustained virologic response

Department of Infectious Diseases, The First Affiliated Hospital of Harbin Medical University

摘要

摘要: 目前普遍认为慢性丙型肝炎患者接受干扰素联合利巴韦林治疗方案获得持续病毒学应答等同于治愈,但临床上可观察到部分患者在获得持续病毒学应答后发生了肝细胞癌(HCC)。归纳并分析了近些年关于慢性丙型肝炎患者在获得持续病毒学应答后发生HCC的相关研究,总结了可能与HCC发生相关的危险因素。分析表明如男性、高龄、肝硬化、糖尿病等危险因素可能与HCC发生相关,但仍有为数不少的危险因素有待进一步研究。
- 肝炎,丙型,慢性 /
- 持续病毒学应答 /
- 癌,肝细胞 /
- 综述
Abstract: Nowadays it is generally believed that chronic hepatitis C patients who are treated with interferon combined with ribavirin and achieve sustained virologic response are considered cured, but in clinical practice, some patients develop hepatocellular carcinoma (HCC) after achieving sustained virologic response.This article summarizes and analyzes the studies on chronic hepatitis C patients who developed HCC after achieving sustained virologic response and identifies the risk factors for the development of HCC.It has been proved that some of the risk factors, such as male sex, age, liver cirrhosis, and diabetes, may be related to the development of HCC, but a lot of risk factors still await for further investigation.
- hepatitis C /
- chronic /
- sustained virologic response /
- carcinoma

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参考文献(40)

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