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早期AFP应答对经肝动脉化疗栓塞术后中期肝细胞癌患者预后的预测价值

夏冬东 王恩鑫 王文军 白苇 袁洁 韩国宏

夏冬东, 王恩鑫, 王文军, 白苇, 袁洁, 韩国宏. 早期AFP应答对经肝动脉化疗栓塞术后中期肝细胞癌患者预后的预测价值[J]. 临床肝胆病杂志, 2017, 33(6): 1120-1125. DOI: 10.3969/j.issn.1001-5256.2017.06.021.
引用本文: 夏冬东, 王恩鑫, 王文军, 白苇, 袁洁, 韩国宏. 早期AFP应答对经肝动脉化疗栓塞术后中期肝细胞癌患者预后的预测价值[J]. 临床肝胆病杂志, 2017, 33(6): 1120-1125. DOI: 10.3969/j.issn.1001-5256.2017.06.021.
Xia DongDong, Wang EnXin, Wang WenJun, Bai Wei, Yuan Jie, Han GuoHong. Early alpha-fetoprotein response can predict the prognosis of patients with intermediate-stage hepatocellular carcinoma treated with transarterial chemoembolization[J]. J Clin Hepatol, 2017, 33(6): 1120-1125. DOI: 10.3969/j.issn.1001-5256.2017.06.021.
Citation: Xia DongDong, Wang EnXin, Wang WenJun, Bai Wei, Yuan Jie, Han GuoHong. Early alpha-fetoprotein response can predict the prognosis of patients with intermediate-stage hepatocellular carcinoma treated with transarterial chemoembolization[J]. J Clin Hepatol, 2017, 33(6): 1120-1125. DOI: 10.3969/j.issn.1001-5256.2017.06.021.

早期AFP应答对经肝动脉化疗栓塞术后中期肝细胞癌患者预后的预测价值

DOI: 10.3969/j.issn.1001-5256.2017.06.021
详细信息
  • 中图分类号: R735.7

Early alpha-fetoprotein response can predict the prognosis of patients with intermediate-stage hepatocellular carcinoma treated with transarterial chemoembolization

  • 摘要: 目的对AFP应答进行最佳定义并探讨AFP应答与经肝动脉化疗栓塞术(TACE)治疗BCLC-B期肝细胞癌疗效的关系。方法回顾性纳入2010年1月-2014年12月在西京消化病医院消化介入科行TACE治疗连续的中期肝细胞癌患者116例,利用受试者工作特征曲线确定AFP变化率的最佳临界值,将术后AFP降低程度大于临界值的定义为AFP应答(AFP-R)组,其余为AFP不应答(AFP-NR)组。采用Kaplan-Meier法进行生存分析,生存时间的比较采log-rank检验,利用Cox回归进行多因素预后分析。结果中位肿瘤大小为7.5 cm,112例(96.6%)患者的肝功能为Child-Pugh A级。术后1个月AFP较基线降低16%为最佳临界值。AFP-R组的生存明显高于AFP-NR组,中位生存时间分别为26.6(20.932.3)个月和7.0(5.28.8)个月[风险比(HR)=3.56,95%可信区间(95%CI):2.125.95,P<0.001],在亚组分析中同样能证实AFP-R组的预后明显优于AFPNR组(P值均...

     

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