胆汁酸相关非酒精性脂肪性肝病发病机制及其药物治疗的研究进展

张敏; 黄明星; 郭列军

doi:10.3969/j.issn.1001-5256.2017.06.034

胆汁酸相关非酒精性脂肪性肝病发病机制及其药物治疗的研究进展

DOI: 10.3969/j.issn.1001-5256.2017.06.034

1. 解放军第三〇二医院青少年肝病诊疗与研究中心
2. 中山大学附属第五医院
3. 罗格斯大学环境与职业健康研究所

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2017-01-04
- 出版日期: 2017-06-20

Research advances in the pathogenesis of bile acid-related non-alcoholic fatty liver disease and related pharmacotherapy

Treatment and Research Center of Children's Liver Disease, 302 Hospital of PLA

摘要

摘要: 非酒精性脂肪性肝病发病率增加,已成为一个新的全球卫生问题。非酒精性脂肪性肝炎为其进展形式,预后不良,亟待寻找预防疾病进展并进行治疗的方法。胆汁酸作为一个重要的代谢物和信号分子,能够在肝内和肝外组织调节脂类和碳水化合物代谢以及能量平衡。胆汁酸与其受体如法尼酯X受体和Takeda G蛋白偶联受体5、胆汁酸转运蛋白、肠道菌群等相互作用,可以在不同层面参与非酒精性脂肪性肝病/非酒精性脂肪性肝炎的发病机理。总结了胆汁酸相关非酒精性脂肪性肝病发病机制及其药物治疗的研究进展。
- 脂肪肝 /
- 胆酸类 /
- 受体,G-蛋白偶联 /
- 综述
Abstract: Non-alcoholic fatty liver disease (NAFLD) has become a new health issue in the world due to its increasing incidence rate, and in particular, nonalcoholic steatohepatitis is progressive and has poor prognosis. Therefore, there is an urgent need to search for the methods for the prevention of disease progression and treatment. Bile acid, as an important metabolite and signal molecule, can adjust the metabolism of lipids and carbohydrates and energy balance inside and outside the liver. Bile acid interacts with its receptors, such as the farnesoid X receptor and Takeda G-protein coupled receptor 5, bile acid transporter, and gut microbiota and is involved in the pathogenesis of NAFLD and nonalcoholic steatohepatitis at different levels. This article summarizes the research advances in the pathogenesis of bile acid-related NAFLD and related pharmacotherapy.
- fatty liver /
- cholic acids /
- receptors, G-protein-coupled /
- review

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参考文献(53)

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