Clinical application of indocyanine green clearance test
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摘要: 目前临床上常用的肝功能评价方法多为以血生化检测为代表的静态检测,大多侧重于检测肝脏的损伤程度及功能障碍情况,而对肝脏储备功能,即肝脏的有效功能状态的反映存在明显的局限性。吲哚菁绿(ICG)清除试验是临床中常用肝脏储备功能检测方法,且具有微创、简便、快速、可床边实时监测并短时间重复的特点。ICG清除试验在肝脏外科领域的应用价值已得到广泛认可,近年来,在肝脏内科、肝脏介入、重症患者、药物安全性评估等领域的应用研究逐步深入。现结合近几年的文献,就ICG清除试验的临床应用现状、相关进展及应用前景进行了综述。Abstract: At present, the most commonly used methods for liver function evaluation in clinical practice is static detection represented by blood biochemical examinations, with a focus on the degree of liver injury and liver dysfunction; however, such methods have significant limitations on the reflection of liver reserve function. Indocyanine green (ICG) clearance test is commonly used for the testing of liver reserve function in clinical practice and it is a minimally invasive, simple, and quick procedure available for bedside real-time monitoring and can be repeated during a short period of time. The application value of ICG clearance test in the field of liver surgery has been widely recognized.In recent years, more and more studies have been focusing on the application of ICG clearance test in the fields of internal medicine, liver interventional therapy, critically ill patients, and drug safety assessment. This article reviews the current clinical application, related advances, and future perspectives of ICG clearance test.
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Key words:
- liver function tests /
- indocyanine green /
- liver function tests
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[1]Ministry of Health of the Peoples Republic of China.Diagnosis, management, and treatment of hepatocellular carcinoma (2011 edition) [J].J Clin Hepatol, 2011, 27 (11) :1141-1159. (in Chinese) 中华人民共和国卫生部.原发性肝癌诊疗规范 (2011年版) [J].临床肝胆病杂志, 2011, 27 (11) :1141-1159. [2] DONG JH, ZHENG SS, CHEN XP, et al.Consensus on evaluation of hepatic reserve before hepatectony (2011 edition) [J].Clin J Dig Surg, 2011, 10 (1) :20-25. (in Chinese) 董家鸿, 郑树森, 陈孝平, 等.肝切除术前肝脏储备功能评估的专家共识 (2011版) [J].中华消化外科杂志, 2011, 10 (1) :20-25. [3]LIU YR, FAN ZP, YANG W, et al.Clinical evaluation of liver storage function by indocyanine green retention test[J].Chin J Hepatol, 2010, 18 (6) :476-477. (in Chinese) 刘义荣, 范作鹏, 杨薇, 等.吲哚菁绿滞留测试对肝储备功能的评价[J].中华肝脏病杂志, 2010, 18 (6) :476-477. [4]HAIMERL M, JUNG EM, BEYER LP, et al.Chronic liver disease:Correlation of CEUS-based microperfusion and indocyanine green clearance[J].Clin Hemorheol Microcirc, 2015, 61 (2) :195-204. [5]BIRNBAUM J, LEHMANN C, TAYMOORIAN K, et al.The effect of dopexamine and iloprost on plasma disappearance rate of indocyanine green in patients in septic shock[J].Anaesthesist, 2003, 52 (11) :1014-1019. [6]INAL MT, MEMID, KARGI M, et al.Prognostic value of indocyanine green elimination assessed with Li MON in septic patients[J].J Crit Care, 2009, 24 (3) :329-334 [7]SHENG QS, LANG R, HE Q, et al.Indocyanine green clearance test and model for end-stage liver disease score of patients with liver cirrhosis[J].Hepatobiliary Pancreat Dis Int, 2009, 8 (1) :46-49. [8]YAMAMOTO Y, IKOMA H, MORIMURA R, et al.Clinical analysis of anatomical resection for the treatment of hepatocellular carcinoma based on the stratification of liver function[J].World J Surg, 2014, 38 (5) :1154-1163. [9]de GASPERI A, MAZZA E, PROSPERI M.Indocyanine green kinetics to assess liver function:ready for a clinical dynamic assessment in major liver surgery?[J].World J Surg, 2016, 8 (7) :355-367. [10]OKOCHI O, KANEKO T, SUGIMOTO H, et al.ICG pulse spectrophotometry for perioperative liver function in hepatectomy[J].J Surg Res, 2002, 103 (1) :109-113. [11]SAKKA SG, REINHART K, MEIER-HELLMANN A.Comparison of invasive and noninvasive measurements of indocyanine green plasma disappearance rate in critically ill patients with mechanical ventilation and stable hemodynamics[J].Intensive Care Med, 2000, 26 (10) :1553-1556. [12]IMAMURA H, SANO K, SUGAWARA Y, et al.Assessment of hepatic reserve for indication of hepatic resection:decision tree incorporating indocyanine green test[J].J Hepatobiliary Pancreat Surg, 2005, 12 (1) :16-22. [13]YUAN YF, LI GH, LI MQ, et al.Preoperative evaluation of hepatic functional reserve for patients with primary liver carcinoma[J].Chin J Oncol, 1995, 17 (5) :377-380. (in Chinese) 元云飞, 李国辉, 李绵清, 等.术前肝储备功能评估对原发性肝癌手术的价值[J].中华肿瘤杂志, 1995, 17 (5) :377-380. [14]WESSLAU C, KRUGER R, MAY G.Clinical investigations using indocyanine green clearance for evaluation of liver function in organ donors[J].Transplantology, 1994, 5 (1) :1-3. [15]HORI T, IIDA T, YAGI S, et al.K (ICG) value, a reliable real-time estimator of graft function, accurately predicts outcomes in adult living-donor liver transplantation[J].Liver Transpl, 2006, 12 (4) :605-613. [16]ZHANG JF, LIANG RM, YI WJ, et al.Reasearch of cirrhosis of the liver in patients with hepatic functional reserve assessment by ICG test combine with CTP classification[J].Clin J Chin Med, 2013, 5 (9) :99-101. (in Chinese) 张锦峰, 梁瑞敏, 仪文静, 等.吲哚氰绿试验联合CTP分级对肝硬化病人肝储备功能评估的研究[J].中医临床研究, 2013, 5 (9) :99-101. [17] KANG WW, ZHOU L, LIU XH.A clinical evaluation of indocyanine green clearance test in patients with liver cirrhosis[J].Chin J Dig Surg, 2009, 8 (4) :300-301. (in Chinese) 康玮玮, 周莉, 刘旭华.肝硬化病人吲哚菁绿清除试验的临床评价[J].中华消化外科杂志, 2009, 8 (4) :300-301. [18]SCHEINGRABER S, RICHTER S, IGNA D, et al.Indocyanine green elimination but not bilirubin indicates improvement of graft function during MARS therapy[J].Clin Transplantat, 2007, 21 (6) :689-695. [19]HU SL, HU AR, JIANG SW, et al.Evaluation of indocyanine green clearance test for estimation of prognosis in patients with liver failure[J].Clin Prev Med, 2012, 13 (6) :443-446. (in Chinese) 胡守廉, 胡爱荣, 蒋素文, 等.脉冲式色素浓度分析法吲哚菁绿清除试验在肝衰竭病人预后判断中的价值[J].中国预防医学杂志, 2012, 13 (6) :443-446. [20]LAI RM, WANG MF, ZHU YY.Value of indocyanine green test in evaluating liver reserve function in patients with hepatitis B cirrhosis[J].J Clin Hepatol, 2016, 32 (9) :1739-1742. (in Chinese) 赖瑞敏, 王明芳, 朱月永.吲哚菁绿清除试验对乙型肝炎肝硬化患者肝脏储备功能的评估价值[J].临床肝胆病杂志, 2016, 32 (9) :1739-1742. [21]CHEN MS, LI JQ, ZHANG YQ, et al.Transarterial chemoembolization with high dose iodizes oil for the treatment of large hepatocellularcarcinoma[J].Chin J Oncol, 2001, 23 (2) :165-167. (in Chinese) 陈敏山, 李锦清, 张亚奇, 等.大剂量碘油肝动脉栓塞化疗治疗巨块型肝癌[J].中华肿瘤杂志, 2001, 23 (2) :165-167. [22]XIAO EH, LI MQ, HU GD, et al.Determination of liver reserve function before interventional treatment of liver cancer[J].J Intervent Radiol, 2001, 11 (5) :315-318. (in Chinese) 肖恩华, 李绵清, 胡国栋, 等.肝癌介入治疗前肝脏储备功能检测[J].介入放射学杂志, 2001, 11 (5) :315-318. [23]TANG Z, WAN RR, HU HT, et al.The value of indocyanine green test in evaluating the risk of super-selective trans-arterial chemoembolization for B/C hepatocellular carcinoma in Barcelona Clinical Liver Classification[J].Clin J Exp Surg, 2015, 32 (10) :2365-2367. (in Chinese) 唐哲, 万仁瑞, 胡洪涛, 等.吲哚菁绿实验对巴塞罗那B/C期肝癌患者行经导管动脉化疗栓塞术治疗的风险评估[J].中华实验外科杂志, 2015, 32 (10) :2365-2367. [24]ZIPPRICH A, KUSS O, ROGOWSKI S, et al.Incorporating indocyanin green clearance into the Model for End Stage Liver Disease (MELD-ICG) improves prognostic accuracy in intermediate to advanced cirrhosis[J].Gut, 2010, 59 (7) :963-968. [25]BIRNBAUM J, LEHMANN C, TAYMOORIAN K, et al.The effect of dopexamine and iloprost on plasma disappearance rate of indocyanine green in patients in septic shock[J].Anaesthesist, 2003, 52 (11) :1014-1019. [26]YOON HI, KOOM WS, LEE IJ, et al.The significance of ICG-R15in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma[J].Liver Int, 2012, 32 (7) :1165-1171. [27]LI ZF, CHEN XP.Methods for determination of liver reserve function and its clinical significance[J].Chin J Hepatobiliary Surg, 2006, 12 (10) :714-716. (in Chinese) 李哲夫, 陈孝平.肝脏储备功能的检测方法及意义[J].中华肝胆外科杂志, 2006, 12 (10) :714-716.
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