P53调控细胞凋亡在肝细胞癌治疗中的作用

高斯; 赵相轩; 卢再鸣

doi:10.3969/j.issn.1001-5256.2017.07.038

P53调控细胞凋亡在肝细胞癌治疗中的作用

DOI: 10.3969/j.issn.1001-5256.2017.07.038

中国医科大学附属盛京医院放射科

基金项目:

国家自然科学基金(31240025)；辽宁省自然科学基金(2013023056)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2017-01-16
- 出版日期: 2017-07-20

Role of cell apoptosis regulated by P53 in treatment of hepatocellular carcinoma

Department of Radiology, Shengjing Hospital of China Medical University

Research funding:

摘要

摘要: 在大部分肝细胞癌患者中,P53都存在异常或突变,这就使恢复P53功能成为肝癌治疗中一项引人注目的研究。对P53与Bcl-2蛋白家族、microRNA、TGFβ、HBV、HCV、蛋白激酶B各因子之间的关系和P53在化疗药物中调控细胞凋亡作用的研究进展进行综述,为改进肝癌治疗效果提供有益线索。
- 癌,肝细胞 /
- 基因,p53 /
- 细胞凋亡 /
- 治疗 /
- 综述
Abstract: P53 abnormality or mutation is commonly seen in patients with hepatocellular carcinoma (HCC) , and therefore, restoration of P53 function has become a research hotspot in the treatment of HCC.This article reviews the association of P53 with Bcl-2 protein family, microRNA, TGFβ, HBV, HCV, and AKT and the role of P53 in regulating cell apoptosis, in order to provide clues for improving the therapeutic outcome of HCC.
- carcinoma, hepatocellular /
- genes, p53 /
- apoptosis /
- therapy /
- review

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参考文献(40)

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