let-7在肝细胞癌诊疗中的机制及意义

霍婷婷; 王东旭; 张明智; 赵磊

doi:10.3969/j.issn.1001-5256.2017.07.039

let-7在肝细胞癌诊疗中的机制及意义

DOI: 10.3969/j.issn.1001-5256.2017.07.039

1. 郑州大学第一附属医院肿瘤科
2. 山东大学附属山东省肿瘤医院肝胆外科
3. 济南大学山东省医学科学院医学与科学学院

基金项目:

国家自然科学基金(81272375)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2017-02-27
- 出版日期: 2017-07-20

Mechanism and significance of let-7 in diagnosis and treatment of hepatocellular carcinoma

Department of Oncology, The First Affiliated Hospital of Zhengzhou University

Research funding:

摘要

摘要: microRNA（miRNA）在转录后水平发挥重要的基因调控作用。近年来,随着miRNA在肿瘤发生、发展中的研究成为热点,恶性肿瘤的基因靶向治疗也取得了初步成就。miRNA let-7是最早发现的miRNA之一,可调控细胞周期、血管生成等,尤其是参与调节多种肿瘤细胞的增殖、分化和凋亡;let-7家族多数成员有抑癌基因的作用,在多种肿瘤组织中呈低表达而在恶性肿瘤患者血清中呈高表达;let-7与肝细胞癌（HCC）的侵袭性和耐药性密切相关,表明let-7有望成为肝癌早期诊断标志物,并为HCC治疗提供新的靶点。
- 微RNA /
- 癌,肝细胞 /
- 综述
Abstract: MicroRNA (miRNA) play important roles in post-transcriptional gene regulation.In recent years, miRNA has become a hot topic in the research on the development and progression of tumors, and gene targeting therapy for malignant tumors has achieved preliminary progress.As one of the first discovered miRNA, let-7 can regulate the cell cycle and angiogenesis and is involved in the proliferation, differentiation, and apoptosis of various tumor cells.Most members of the let-7 family can act as tumor suppressor gene and have low expression in various tumor tissues and high expression in the serum of patients with malignant tumors.Let-7 is closely associated with the invasion and drug resistance of hepatocellular carcinoma (HCC) .The studies above show that let-7 might become a new marker for the early diagnosis of HCC and provide new targets for the treatment of HCC.
- microRNAs /
- let-7 /
- carcinoma, hepatocellular

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参考文献(37)

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