HBV/HCV感染诱导肝细胞癌的病理机制

王月姣; 宋海燕; 邢练军; 季光; 郑培勇

doi:10.3969/j.issn.1001-5256.2017.07.040

HBV/HCV感染诱导肝细胞癌的病理机制

DOI: 10.3969/j.issn.1001-5256.2017.07.040

1. 上海中医药大学附属龙华医院脾胃病二科
2. 上海中医药大学脾胃病研究所

基金项目:

国家自然科学基金(81202667)；上海市科委自然基金(972)；

详细信息

中图分类号: R512.6;R735.7
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出版历程
- 收稿日期: 2017-01-20
- 出版日期: 2017-07-20

Pathogenesis of hepatocellular carcinoma induced by HBV and HCV infection

Second Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 肝细胞癌(HCC)是最常见的恶性肿瘤之一。手术是小肝癌的首选治疗方法,但晚期以及术后复发转移仍然缺乏有效治疗手段,导致其病死率高居不下。持续性肝炎病毒感染以HBV和HCV感染为主,是诱导HCC发病的最主要原因。肝炎病毒通过多种信号转导机制改变肝细胞基因表达、阻止或改变免疫反应、调控肝组织微环境,从而促进HCC的发生发展。概述了HBV和HCV感染诱导HCC的病理机制,以期对HCC的防治新途径的开发有一定启示作用。
- 癌,肝细胞 /
- 肝炎病毒 /
- 综述
Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide.Surgery is the preferred therapy for patients with small HCC;however, there still lack effective therapies for advanced HCC and postoperative recurrence and metastasis, leading to its high mortality.Persistent hepatitis virus infection, mainly hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, is the most important cause of HCC.Through various signal transduction mechanisms, hepatitis virus changes gene expression in hepatocytes, blocks or alters immune response, regulates the microenvironment in the liver, and thus promotes the development and progression of HCC.This article reviews the pathogenesis of HCC induced by HBV and HCV infection, in order to provide new approaches for the prevention and treatment of HCC.
- carcinoma, hepatocellular /
- hepatitis viruses /
- review

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