外泌体与病毒感染及HBV相关肝病的关系

贾小芳; 褚巧芳; 袁正宏

doi:10.3969/j.issn.1001-5256.2017.08.010

外泌体与病毒感染及HBV相关肝病的关系

DOI: 10.3969/j.issn.1001-5256.2017.08.010

1. 上海市公共卫生临床中心复旦大学
2. 医学分子病毒学教育部/卫生部重点实验室基础医学院病原生物学系上海医学院复旦大学

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2017-07-04
- 出版日期: 2017-08-20

Association of exosomes with viral infection and hepatitis B virus-related liver diseases

Shanghai Public Health Clinical Center, Fudan University

摘要

摘要: HBV感染后可导致肝脏组织炎症和肝细胞坏死,甚至发生肝纤维化等病理变化,驱动着"慢性肝炎-肝硬化-肝癌"的进展,但其机制尚不完全明了。被HBV感染的肝细胞与其他未感染细胞及宿主免疫系统之间发生相互作用的可能机制即通过肝脏微环境中由外泌体介导的细胞与细胞间的相互沟通。多项研究表明病毒感染可以调节外泌体的生成并影响其组成,病毒microRNA、蛋白质甚至整个病毒都可能被包裹进入外泌体,从而影响病毒的免疫识别或调节邻近细胞的功能。阐述了外泌体的产生和组成,及其在病毒感染过程中的作用,并进一步对外泌体与HBV感染等方面的研究进展进行了讨论。
- 外泌体 /
- 肝炎病毒,乙型 /
- 肝疾病
Abstract: Hepatitis B virus ( HBV) infection causes pathological changes of the liver, including liver inflammation, hepatocyte necrosis, and even liver fibrosis, and promotes the progression from chronic hepatitis to liver cirrhosis and liver cancer, but related mechanisms remain unclear. The mechanism for the interaction between hepatocytes infected by HBV and uninfected hepatocytes/host immune system might be exosomes-mediated cell-cell communication in liver microenvironment. Many studies have demonstrated that viral infection can regulate the production of exosomes and affect their composition, and viral microRNAs, proteins, and even the entire virion can be incorporated into the exosomes, which can affect the immune recognition of viruses or regulate the function of adjacent cells. This article elaborates on the production and composition of exosomes and their roles in viral infection, as well as the research advances in the association between exosomes and HBV infection.
- exosomes /
- hepatitis B virus /
- liver diseases

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