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Risk factors for hypertriglyceridemia-induced acute pancreatitis
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摘要: 目的探讨高甘油三酯血症相关性急性胰腺炎发病的相关危险因素,为临床防治提供参考。方法选取四川省广安市人民医院2014年1月-2016年6月收治的高甘油三酯血症相关性急性胰腺炎患者42例作为研究组,另选取同期收治的42例非高甘油三酯血症相关性急性胰腺炎患者（胆源性和酒精性）作为对照组。对两组入选患者就诊时的性别、年龄、合并脂肪肝、BMI、合并2型糖尿病、合并高脂血症、高脂血症家族史、血清甘油三酯、血清胆固醇、LDL、HDL、全血低切黏度、全血高切黏度及D-二聚体浓度等指标进行比较分析。计量资料两组间比较采用t检验;计数资料组间比较采用χ2检验。将单因素分析中有统计学意义的变量再进行多因素非条件logistic回归分析。结果单因素分析结果显示,性别、合并脂肪肝、BMI、合并2型糖尿病、合并高脂血症、高脂血症家族史、血清甘油三酯水平、全血低切黏度、全血高切黏度及D-二聚体浓度在两组间差异均有统计学意义（P值均<0.05）;多因素非条件logistic回归分析显示,合并2型糖尿病[比值比（OR）=2.206,95%可信区间（95%CI）:1.1254.263,P=0....Abstract: Objective To investigate the risk factors for hypertriglyceridemia-induced acute pancreatitis, and to provide a reference for clinical prevention and treatment. Methods A total of 42 patients with hypertriglyceridemia-induced acute pancreatitis who were admitted to The People's Hospital of Guang'an from January 2014 to June 2016 were enrolled as study group, and 42 patients with non-hypertriglyceridemia-induced acute pancreatitis ( biliary or alcoholic) were enrolled as control group. The two groups were compared in terms of sex, age, fatty liver, body mass index ( BMI) , type 2 diabetes, hyperlipidemia, family history of hyperlipidemia, serum triglyceride, serum cholesterol, low-density lipoprotein ( LDL) , high-density lipoprotein ( HDL) , whole blood low-shear viscosity, and D-dimer concentration at the time when they visited the hospital. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. A multivariate non-conditional logistic regression analysis was performed for the statistically significant variables identified in the univariate analysis. Results The univariate analysis showed that there were significant differences between the two groups in sex, fatty liver, BMI, type 2 diabetes, hyperlipidemia, family history of hyperlipidemia, serum triglyceride level, whole blood low-shear viscosity, whole blood high-shear viscosity, and D-dimer concentration ( all P < 0. 05) . The multivariate non-conditional logistic regression analysis showed that type 2 diabetes ( odds ratio [OR]= 2. 206, 95% confidence interval[95% CI]: 1. 125-4. 263, P = 0. 024) , serum triglyceride level ( OR = 5. 253, 95% CI: 2. 502-9. 568, P = 0. 001) , BMI ( OR =3. 812, 95% CI: 1. 896-7. 529, P = 0. 011) , fatty liver ( OR = 4. 255, 95% CI: 2. 185-8. 236, P = 0. 009) , and D-dimer concentration ( OR = 6. 258, 95% CI: 3. 526-11. 653, P = 0. 006) were independent risk factors for hypertriglyceridemia-induced acute pancreatitis. Conclusion It is of great clinical significance to provide intervention for risk factors for hypertriglyceridemia-induced acute pancreatitis and minimize its incidence rate.
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Key words:
- pancreatitis /
- hypertriglyceridemia /
- risk factors
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