基因1b型慢性丙型肝炎患者血清铁蛋白水平与聚乙二醇干扰素抗病毒疗效的关系

游春芳; 周利民; 邓薇

doi:10.3969/j.issn.1001-5256.2017.09.016

基因1b型慢性丙型肝炎患者血清铁蛋白水平与聚乙二醇干扰素抗病毒疗效的关系

DOI: 10.3969/j.issn.1001-5256.2017.09.016

自贡市第一人民医院感染科

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中图分类号: R512.63
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出版历程
- 收稿日期: 2017-03-08
- 出版日期: 2017-09-20

Correlation between serum ferritin level and antiviral effect of pegylated interferon in chronic hepatitis C patients with genotype 1b

Department of Infectious Diseases, The First People's Hospital of Zigong

摘要

摘要: 目的探讨分析慢性丙型肝炎（CHC）患者血清铁蛋白（SF）水平与PEG-IFNα-2a疗效的相关性。方法选取2013年11月-2014年7月自贡市第一人民医院收治的85例CHC患者,均给予PEG-IFNα-2a,180μg,皮下注射,每周1次,同时联合利巴韦林口服1015 mg·kg-1·d-1,疗程48周,治疗结束后随访24周。在0周时检测SF,在0、4、12、24、48及72周检测HCV RNA以判断疗效。根据疗效分为快速病毒学应答组（RVR）、早期病毒学应答组（EVR）、持续病毒学应答组（SVR）、无应答组、复发组;根据SF水平分为高SF组（≥400 ng/ml）与低SF组（<400 ng/ml）。计量资料多组间比较采用方差分析,进一步两两比较采用SNKq检验;计数资料组间比较采用χ2检验;相关性分析采用Spearman秩相关性分析。结果 85例CHC患者中获得RVR 36例（42.35%）,EVR 70例（82.35%）,SVR 68例（80.00%）,无应答15例（17.65%）,复发...
- 肝炎,丙型,慢性 /
- 铁蛋白质类 /
- 干扰素α-2a /
- 治疗
Abstract: Objective To investigate the correlation between serum ferritin ( SF) level and antiviral effect of pegylated interferon-α-2a ( Peg-IFNα-2a) in chronic hepatitis C ( CHC) patients. Methods A total of 85 CHC patients who were admitted to The First People's Hospital of Zigong from November 2013 to July 2014 were enrolled and treated with subcutaneous injection of Peg-IFNα-2a 180 μg once a week combined with oral ribavirin 10-15 mg·kg-1·d-1. The course of treatment was 48 weeks and the patients were followed up for 24 weeks after the treatment ended. SF was measured at week 0, and HCV RNA was measured at weeks 0, 4, 12, 24, 48, and 72 to evaluate therapeutic outcome. According to the therapeutic outcome, the patients were divided into rapid virologic response ( RVR) group, early virologic response ( EVR) group, sustained virologic response ( SVR) group, no response group ( NR group) , and recurrence group; according to the SF level, the patients were divided into high-SF group ( ≥400 ng/ml) and low-SF group ( < 400 ng/ml) . An analysis of variance was used for comparison of continuous data between groups, and SNK-q test was used for comparison between any two groups; the chi-square test was used for comparison of categorical data between groups, and Spearman rank correlation was used for correlation analysis. Results Of all patients, 36 ( 42. 35%) achieved RVR, 70 ( 82. 35%) achieved EVR, 68 ( 80. 00%) achieved SVR, 15 ( 17. 65%) had no response, and 2 ( 2. 35%) experienced recurrence. The NR group and recurrence group had a significant increase in SF level, and the NR group had a significantly higher SF level than RVR group ( 1489. 15 ± 278. 21 ng/ml vs 398. 12 ± 252. 45 ng/ml, q = 10. 826, P < 0. 01) , EVR group ( 1489. 15 ± 278. 21 ng/ml vs 514. 85 ± 275. 64 ng/ml, q = 10. 151, P < 0. 01) , and SVR group ( 1489. 15 ± 278. 21 ng/ml vs486. 45 ± 251. 60 ng/ml, q = 10. 614, P < 0. 01) . SF level was negatively correlated with the therapeutic effect of PEG-IFN ( rs=-0. 688, P< 0. 001) . Compared with the high-SF group, the low-SF group had a significantly higher proportion of patients who achieved RVR ( 85. 29% vs13. 73%, P < 0. 001) , EVR ( 100% vs 70. 59%, P < 0. 001) , or SVR ( 100% vs 66. 67%, P < 0. 001) and a significantly lower proportion of patients who had no response ( 0 vs 29. 41%, P < 0. 001) . Conclusion In CHC patients, SF level before treatment is correlated with the antiviral effect of PEG-IFN, suggesting that SF level can predict the antiviral effect of PEG-IFN in CHC patients.
- hepatitis C, chronic /
- ferritins /
- interferon alfa-2a /
- therapy

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